RORγT is overexpressed in iNKT and γδ T cells during relapse in relapsing-remitting multiple sclerosis

Zarobkiewicz, Michał K.; Kowalska, Wioleta; Halczuk, Paweł; Woś, Justyna; Jodłowska‐Jędrych, Barbara; Rejdak, Konrad; Roliński, Jacek

doi:10.1016/j.jneuroim.2019.577046

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…An increase was, however, observed after treatment with recombinant IFNβ in a group of patients well responding to this therapy [24]. The former stays in contrast to our results-we observed no significant difference in peripheral blood iNKT percentage between patients in remission or relapse of RRMS and healthy volunteers [30]. Nevertheless, we have observed functional differences-overexpression of RORγT and IL-23R in iNKT both during relapse and remission of RRMS, moreover, we noted a significant rise in iNKT17 during remission.…”

Section: Inkt In Mscontrasting

confidence: 99%

NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

Zarobkiewicz

Morawska

Michalski

et al. 2021

IJMS

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NKT cells comprise three subsets—type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases—multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models.

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Section: Inkt In Mscontrasting

confidence: 99%

NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

Zarobkiewicz

Morawska

Michalski

et al. 2021

IJMS

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“…Expression of FOXP3, EBI3 and GATA3 in lymphocytes of RRMS patients decreased, with an increased RORC/FOXP3 gene expression ratio [55]. Overexpression of RORC in γδ T cellss and iNKT cellss of RRMS patients in relapse was also detected [56].…”

Section: Jak-stat Pathways In Multiple Sclerosismentioning

confidence: 94%

Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences

Szewczak

Donskow‐Łysoniewska

2020

Biomedicines

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Autoimmune diseases are increasingly recognized as disease entities in which dysregulated cytokines contribute to tissue-specific inflammation. In organ-specific and multiorgan autoimmune diseases, the cytokine profiles show some similarities. Despite these similarities, the cytokines have different roles in the pathogenesis of different diseases. Altered levels or action of cytokines can result from changes in cell signaling. This article describes alterations in the JAK-STAT, TGF-β and NF-κB signaling pathways, which are involved in the pathogenesis of multiple sclerosis and systemic lupus erythematosus. There is a special focus on T cells in preclinical models and in patients afflicted with these chronic inflammatory diseases.

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“…Detailed characteristics are presented in Table 1 . Inclusion criteria were as in our previous study [ 17 ]: I. no other autoimmunological disease diagnosed, II. no glucocorticoid treatment during 4 weeks prior to blood collection, and III.…”

Section: Methodsmentioning

confidence: 99%

“…Staining and flow cytometry was performed as previously [ 17 ]. First, antibodies for surface staining were added to 100 uL of whole peripheral blood.…”

Section: Methodsmentioning

confidence: 99%

IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis

Zarobkiewicz

Kowalska

Morawska

et al. 2021

JCM

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Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset of IL-15-producing γδ T cells that correlate with disease severity. The aim of the current study was to test whether such a subset is also present in humans and its importance for the pathogenesis of MS. The peripheral blood from 29 patients with relapsing-remitting MS (including 6 relapses) and 22 controls was stained with monoclonal antibodies and analyzed with flow cytometry. The existence of IL-15+ γδ T cells was confirmed. Moreover, the percentage of IL-15+ γδ T is significantly increased in MS patients and correlates with disease severity. Nevertheless, additional functional studies are needed to fully understand the importance of those cells in multiple sclerosis pathogenesis

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RORγT is overexpressed in iNKT and γδ T cells during relapse in relapsing-remitting multiple sclerosis

Cited by 6 publications

References 30 publications

NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

NKT and NKT-like Cells in Autoimmune Neuroinflammatory Diseases—Multiple Sclerosis, Myasthenia Gravis and Guillain-Barre Syndrome

Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences

IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis

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