ROS Cocktails as an Adjuvant for Personalized Antitumor Vaccination?

Clemen, Ramona; Bekeschus, Sander

doi:10.3390/vaccines9050527

Cited by 13 publications

(14 citation statements)

References 96 publications

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“…These findings corroborated previous reports on increased T-cell infiltrates in plasma-treated syngeneic melanomas in vivo [ 196 , 197 ]. In addition, it was recently shown in vitro and in vivo that the immunogenicity plasma-treated protein can confer immunoprotection in mice against melanoma growth [ 198 ], giving rise to entire novel concepts in plasma oncotherapy [ 199 ].…”

Section: Immune Cell Activation Followed By Plasma Treatmentmentioning

confidence: 99%

Cold Physical Plasma in Cancer Therapy: Mechanisms, Signaling, and Immunity

Faramarzi

Zafari

Alimohammadi

et al. 2021

Oxidative Medicine and Cellular Longevity

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Despite recent advances in therapy, cancer still is a devastating and life-threatening disease, motivating novel research lines in oncology. Cold physical plasma, a partially ionized gas, is a new modality in cancer research. Physical plasma produces various physicochemical factors, primarily reactive oxygen and nitrogen species (ROS/RNS), causing cancer cell death when supplied at supraphysiological concentrations. This review outlines the biomedical consequences of plasma treatment in experimental cancer therapy, including cell death modalities. It also summarizes current knowledge on intracellular signaling pathways triggered by plasma treatment to induce cancer cell death. Besides the inactivation of tumor cells, an equally important aspect is the inflammatory context in which cell death occurs to suppress or promote the responses of immune cells. This is mainly governed by the release of damage-associated molecular patterns (DAMPs) to provoke immunogenic cancer cell death (ICD) that, in turn, activates cells of the innate immune system to promote adaptive antitumor immunity. The pivotal role of the immune system in cancer treatment, in general, is highlighted by many clinical trials and success stories on using checkpoint immunotherapy. Hence, the potential of plasma treatment to induce ICD in tumor cells to promote immunity targeting cancer lesions systemically is also discussed.

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Section: Immune Cell Activation Followed By Plasma Treatmentmentioning

confidence: 99%

Cold Physical Plasma in Cancer Therapy: Mechanisms, Signaling, and Immunity

Faramarzi

Zafari

Alimohammadi

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Sterile inflammation via damage-associated molecular patterns (DAMPs) overrides the immunosuppressive properties associated with apoptosis, which drives dendritic cell (DC) maturation and anti-tumor T cell responses [238]. The importance of immunity [239], immunogenicity, and antigen presentation [239], ICD [240], and vaccination [241], [242] for plasma cancer treatment has been extensively reviewed recently. Increased immunogenicity has been described in several in vitro studies [148], [243]- [249], and a number of reports suggest an enhancement of the anti-tumor immune function following plasma cancer treatment in vivo [250]- [253].…”

Section: B Challenges and Proposed Solutionsmentioning

confidence: 99%

“…A new research field and potential therapeutic approach has been recently opened up by investigating the immunogenicity of proteins, showing that plasma-treated chicken ovalbumin, a model protein, provided enhanced protein immuno-recognition in vitro and tumor growth reduction in vivo, [133]. The implications of these findings for tumor vaccination and therapeutics are vast and provide a basis for further investigation [242].…”

Section: B Challenges and Proposed Solutionsmentioning

confidence: 99%

Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

Laroussi

Bekeschus

Keidar

et al. 2022

IEEE Trans. Radiat. Plasma Med. Sci.

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Plasma, the fourth and most pervasive state of matter in the visible universe, is a fascinating medium that is connected to the beginning of our universe itself. Man-made plasmas are at the core of many technological advances that include the fabrication of semiconductor devices, which enabled the modern computer and communication revolutions. The introduction of low temperature, atmospheric pressure plasmas to the biomedical field has ushered a new revolution in the healthcare arena that promises to introduce plasma-based therapies to combat some thorny and long-standing medical challenges. This article presents an overview of where research is at today and discusses innovative concepts and approaches to overcome present challenges and take the field to the next level. It is written by a team of experts who took an in-depth look at the various applications of plasma in hygiene, decontamination, and medicine, made critical analysis, and proposed ideas and concepts that should help the research community focus their efforts on clear and practical steps necessary to keep the field advancing for decades to come.

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“… 206 , 207 This promotes the underexplored idea of using ROS as an immune‐enhancer and in autologous anticancer vaccination. 208 …”

Section: Gas Plasma Technology For Ulcerating Breast Cancer Combinati...mentioning

confidence: 99%

The potential of gas plasma technology for targeting breast cancer

Bekeschus

Saadati

Emmert

2022

Clinical & Translational Med

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Despite therapeutic improvements in recent years, breast cancer remains an often fatal disease. In addition, breast cancer ulceration may occur during late stages, further complicating therapeutic or palliative interventions. In the past decade, a novel technology received significant attention in the medical field: gas plasma. This topical treatment relies on the partial ionization of gases that simultaneously produce a plethora of reactive oxygen and nitrogen species (ROS/RNS). Such local ROS/RNS overload inactivates tumour cells in a non‐necrotic manner and was recently identified to induce immunogenic cancer cell death (ICD). ICD promotes dendritic cell maturation and amplifies antitumour immunity capable of targeting breast cancer metastases. Gas plasma technology was also shown to provide additive toxicity in combination with radio and chemotherapy and re‐sensitized drug‐resistant breast cancer cells. This work outlines the assets of gas plasma technology as a novel tool for targeting breast cancer by summarizing the action of plasma devices, the roles of ROS, signalling pathways, modes of cell death, combination therapies and immunological consequences of gas plasma exposure in breast cancer cells in vitro, in vivo, and in patient‐derived microtissues ex vivo.

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ROS Cocktails as an Adjuvant for Personalized Antitumor Vaccination?

Cited by 13 publications

References 96 publications

Cold Physical Plasma in Cancer Therapy: Mechanisms, Signaling, and Immunity

Cold Physical Plasma in Cancer Therapy: Mechanisms, Signaling, and Immunity

Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

The potential of gas plasma technology for targeting breast cancer

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