ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor

Wan, Shuang‐Shuang; Zeng, Jing-Yue; Cheng, Han; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2018.09.004

Cited by 221 publications

(147 citation statements)

References 43 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…Since gases could diffuse into deep tissues, endogenous gasotransmitters like nitric oxide (NO), [ 22–24 ] carbon monoxide (CO), [ 25 ] and hydrogen sulfide (H 2 S) [ 26 ] as therapeutic agents have been widely studied due to their anticancer effects under high concentrations. [ 27 ] Compared with CO and H 2 S, NO has been applied in clinical treatments for a variety of diseases such as hypertension and atherosclerosis, which is considered to be safer for therapy applications.…”

Section: Methodsmentioning

confidence: 99%

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Peng

et al. 2020

Advanced Materials

View full text Add to dashboard Cite

Traditional phototherapies face the issue that the insufficient penetration of light means it is difficult to reach deep lesions, which greatly reduces the feasibility of cancer therapy. Here, an implantable nitric oxide (NO)‐release device is developed to achieve long‐term, long‐distance, remote‐controllable gas therapy for cancer. The device consists of a wirelessly powered light‐emitting diode (wLED) and S‐nitrosoglutathione encapsulated with poly(dimethylsiloxane) (PDMS), obtaining the NO‐release wLED (NO‐wLED). It is found that NO release from the NO‐wLED can be triggered by wireless charging and the concentration of produced NO reaches 0.43 × 10−6 m min−1, which can achieve a killing effect on cancer cells. In vivo anticancer experiments exhibit obvious inhibitory effect on the growth of orthotopic cancer when the implanted NO‐wLED is irradiated by wireless charging. In addition, recurrence of cancer can be prevented by NO produced from the NO‐wLED after surgery. By illumination in the body, this strategy overcomes the poor penetration and long‐wavelength dependence of traditional phototherapies, which also provides a promising approach for in vivo gas therapy remote‐controlled by wireless charging.

show abstract

Section: Methodsmentioning

confidence: 99%

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Peng

et al. 2020

Advanced Materials

View full text Add to dashboard Cite

show abstract

“…Wan simultaneously demonstrated biomimetic technology and photodynamic therapy on a nanoplatform. Considering the limitations of photodynamic therapy (resistance to reactive oxygen species and unstable treatment efficiency), gas therapy was added to the platform [87]. On the one hand, L-Arg activated photodynamic therapy under near-infrared conditions, and on the other hand, L-Arg acted as an oxidant to cause nitrification to produce NO.…”

Section: Mofs-based Bionic Immune Escape Strategymentioning

confidence: 99%

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

View full text Add to dashboard Cite

In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

show abstract

“…[25] X-PDT requires the use of nanoparticles that can absorb X-ray to emit light capable of triggering ap hotosensitizer through energy transfer.Because X-rays have good tissue penetration capability and can reach at umor that cannot be reached by other light source,X-PDT can treat tumors deep in the tissue, making it af rontier in PDT research. [25f,26] Fore xample, nanoparticles with ac omposition of (n-Bu 4 N) 2 [Mo 6 I 8 -(OCOCF 3 ) 6 ]t hat contained ah eavy element molybdenum were found to be able to absorb X-ray to become excited triplet states,w hich led to the formation of 1 killing cancer cells. [26] In another example,n anoparticles made of both X-ray sensitive SrAl 2 O 4 :Eu 2+ (SAO) and photosensitizer (merocyanine 540, MC540) were used to absorb X-rays to emit visible light that activated PDT, converting 3 O 2 into 1 O 2 for killing cancer cells and shrinking tumors ( Figure 2).…”

Section: Daylightmentioning

confidence: 99%

“…Photodynamic therapy (PDT) is acancer therapy method with minimal invasiveness and is different from other lighttriggered cancer therapies such as photothermal therapy. [1] This form of treatment requires the presence of three components to be considered effective,t hese are oxygen, light, and ap hotosensitizer (PS). [2] Thel ight activates the photosensitizer to produce lethal reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ), by transferring energy to ground-state oxygen present in the system via triplet state energy transfer.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

2019

View full text Add to dashboard Cite

The viable use of photodynamic therapy (PDT) in cancer therapy has never been fully realized because of its undesirable effects on healthy tissues. Herein we summarize some physicochemical factors that can make PDT a more viable and effective option to provide future oncological patients with better‐quality treatment options. These physicochemical factors include light sources, photosensitizer (PS) carriers, microwaves, electric fields, magnetic fields, and ultrasound. This Review is meant to provide current information pertaining to PDT use, including a discussion of in vitro and in vivo studies. Emphasis is placed on the physicochemical factors and their potential benefits in overcoming the difficulty in transitioning PDT into the medical field. Many advanced techniques, such as employing X‐rays as a light source, using nanoparticle‐loaded stem cells and bacteriophage bio‐nanowires as a photosensitizer carrier, as well as integration with immunotherapy, are among the future directions.

show abstract

ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor

Cited by 221 publications

References 43 publications

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Nitric Oxide Release Device for Remote‐Controlled Cancer Therapy by Wireless Charging

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

Contact Info

Product

Resources

About