ROS-reactive PMS/PC drug delivery system improves new bone formation under diabetic conditions by promoting angiogenesis-osteogenesis coupling via down-regulating NOX2-ROS signalling axis

Wu, Zimei; Hou, Qiaodan; Chen, Tingting; Jiang, Xingzhu; Wang, Lulu; Xu, Jing; Wang, Lin

doi:10.1016/j.biomaterials.2022.121900

Cited by 24 publications

(10 citation statements)

References 59 publications

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“…The redox process is critical to the activities of life, and maintaining the dynamic balance of redox is crucial for maintaining good health. − Intracellular energy is sourced from redox reactions, and the regulation of redox is closely tied to various diseases, making redox drug development an easier feat. − The overproduction of ROS and RNS leads to oxidative stress in living organisms and can result in the development of various diseases such as cardiovascular disease, diabetes mellitus (DM), and cancer, among others. − GSH, a major thiol antioxidant present ubiquitously in cells and biological tissues, is capable of scavenging free ROS and preventing oxidative stress. − However, the development of many diseases also involves GSH such that the levels of GSH are increased in tumor tissue. − Consequently, the design of redox-responsive probes is crucial in the sensing, imaging, diagnosis, and prognosis of diseases.…”

Section: Ratiometric Pa Imagingmentioning

confidence: 99%

Activatable Probes for Ratiometric Imaging of Endogenous BiomarkersIn Vivo

Fu,

Yang,

Wang

et al. 2024

ACS Nano

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Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological and pathological states. Therefore, it is crucial to design imaging systems capable of realtime detection of dynamic changes in biomarkers for the accurate diagnosis and effective treatment of diseases. Recently, ratiometric imaging has emerged as a widely used technique for sensing and imaging of biomarkers due to its advantage of circumventing the limitations inherent to conventional intensity-dependent signal readout methods while also providing built-in self-calibration for signal correction. Here, the recent progress of ratiometric probes and their applications in sensing and imaging of biomarkers are outlined. Ratiometric probes are classified according to their imaging mechanisms, and ratiometric photoacoustic imaging, ratiometric optical imaging including photoluminescence imaging and self-luminescence imaging, ratiometric magnetic resonance imaging, and dual-modal ratiometric imaging are discussed. The applications of ratiometric probes in the sensing and imaging of biomarkers such as pH, reactive oxygen species (ROS), reactive nitrogen species (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, and hypoxia are discussed in detail. Additionally, this Review presents an overview of challenges faced in this field along with future research directions.

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Section: Ratiometric Pa Imagingmentioning

confidence: 99%

Activatable Probes for Ratiometric Imaging of Endogenous BiomarkersIn Vivo

Fu,

Yang,

Wang

et al. 2024

ACS Nano

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“…[11] Although the oxidation potentials of PMS and PS are 1.82 V and 2.01 V, respectively, their direct reaction rate with organic matter is low, and external activation is required to produce radicals. [12] Compared to PS, PMS is structurally asymmetric and has longer OÀ O bonds, making it more likely to be activated. Previous literature has demonstrated that PMS can efficiently decompose various refractory organic matter, such as common dyes, endocrine disruptors, antibiotics, and cyanobactertoxins.…”

Section: -Induced Fenton-like Degradation Mechanismmentioning

confidence: 99%

Progress of Copper‐based Nanocatalysts in Advanced Oxidation Degraded Organic Pollutants

Li,

You,

et al. 2024

ChemCatChem

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To address global pollution caused by contaminants in water bodies, it is crucial to develop an efficient and environmentally friendly treatment process for wastewater from various industries. Advanced oxidation processes (AOPs) have proven to be highly effective in wastewater treatment due to their high oxidation efficacy and the absence of secondary pollutants. Different methods such as ozone, Fenton, electrochemical, photolysis, and sonolysis can be used in AOPs to degrade emerging pollutants that are resistant to conventional methods. In recent years, nanotechnology has emerged as a viable solution, with various nanomaterials being developed for wastewater treatment. Among them, copper‐based nanocatalysts have shown great potential in AOPs. This review focuses on the progress and mechanisms of copper‐based nanocatalysts in wastewater treatment via AOPs. It also discusses the challenges associated with oxidation, electrochemistry, Fenton, and photocatalysis in wastewater treatment processes.

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“…By lowering the ROS level in BMSCs, mitochondrial function of BMSCs increased, which leading to decreased apoptosis and high totipotency, 5,6 as well as enhanced osteogenesis and bone repairment 6 . Functional modification of bone repair materials, which reduce ROS bone locally, will help bone integration and regeneration 2,6,7 …”

Section: Introductionmentioning

confidence: 99%

“…6 Functional modification of bone repair materials, which reduce ROS bone locally, will help bone integration and regeneration. 2,6,7 Electrospinning, an effective method for preparing artificial periosteum, could produce highly porous non-woven fabrics consisting of ultrafine fibers, which can guide the repair of bone defects and facilitate the scaffold-tissue integration. [8][9][10] Polycaprolactone (PCL) is a biodegradable polyester material that has excellent electro-spinnability, good biocompatibility, and low immunogenicity.…”

mentioning

confidence: 99%

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Feng

Huang

Liu

et al. 2023

J Biomedical Materials Res

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Segmental bone defects caused by trauma, tumor resection or congenital malformations are often reconstructed with autologous, allogeneic bone grafts or artificial bone materials, of which, about 5% ~ 10% will have delayed healing or even nonunion of fractures. The loss of periosteum and excessive accumulation of ROS in fracture site leads to the aging of osteoblasts and the decline of their proliferation and differentiation, thus affecting the fracture healing process. In this study, we prepared a functional modified artificial periosteum β‐TCP/MnO2/PCL(β‐TMP) by electrospinning with a function of catalyzing decomposition of H2O2. We examined the surface morphology of β‐TMP, the concentration of Ca, P and Mn of β‐TMP, as well as the diameter distribution range of nanofibers on β‐TMP. Through X‐ray diffraction patterns and Fourier transform infrared spectra, β‐TMP was characterized and its hydrophilicity was tested. The release of Mn2+ and Ca2+ of 0.1 and 0.05% β‐TMP in different pH values (7.4 and 5.5) determined by ICP. We also identified that β‐TMP could reduce the level of ROS in cells by lowering the level of H2O2. 0%, 0.05% and 0.1% β‐TMP displayed good cell compatibility, cell adhesion and cellular morphology in the condition with or without H2O2. 0.5% β‐TMP showed compromised cell compatibility in normal condition, however, the compromised phenotypes could be partially rescued in the present of H2O2. Compared with 0%, 0.05% and 0.1% β‐TMP displayed higher osteoblastic differentiation with or without H2O2 in BMSCs as well as in MG‐63. In sum, β‐TMP helped osteogenesis and promoted repair of bone defects.

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ROS-reactive PMS/PC drug delivery system improves new bone formation under diabetic conditions by promoting angiogenesis-osteogenesis coupling via down-regulating NOX2-ROS signalling axis

Cited by 24 publications

References 59 publications

Activatable Probes for Ratiometric Imaging of Endogenous BiomarkersIn Vivo

Activatable Probes for Ratiometric Imaging of Endogenous BiomarkersIn Vivo

Progress of Copper‐based Nanocatalysts in Advanced Oxidation Degraded Organic Pollutants

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

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ROS-reactive PMS/PC drug delivery system improves new bone formation under diabetic conditions by promoting angiogenesis-osteogenesis coupling via down-regulating NOX2-ROS signalling axis

Cited by 24 publications

References 59 publications

Activatable Probes for Ratiometric Imaging of Endogenous BiomarkersIn Vivo

Activatable Probes for Ratiometric Imaging of Endogenous BiomarkersIn Vivo

Progress of Copper‐based Nanocatalysts in Advanced Oxidation Degraded Organic Pollutants

Functional β‐TCP/MnO2/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level

Contact Info

Product

Resources

About

Functional β‐TCP/MnO₂/PCL artificial periosteum promoting osteogenic differentiation of BMSCs by reducing locally reactive oxygen species level