ROS-Responsive Polymeric Micelle for Improving Pesticides Efficiency and Intelligent Release

Abstract

The low utilization rate of pesticides causes serious problems such as food safety and environmental pollution. Stimulus-responsive release can effectively improve the utilization rate of pesticides. Reactive oxygen species (ROS) burst, as an early event of plant−pathogen interaction, can stimulate the release of pesticides. In this work, a polymeric micelle with ROS-responsive was prepared and then Validamycin (Vail) was loaded into polymeric micelle to prepare Vail-loaded polymeric micelle. The Vailloaded polymeric micelle displayed excellent ROS-dependent release kinetics. In vitro and in vivo antifungal experiments confirmed that the Vail-loaded polymeric micelle could improve antifungal efficacy against Rhizoctonia solani than with the Vail reagent. Therefore, as a biostimulation and controlled release system, ROS-responsive polymeric micelles can improve the utilization rate of pesticides and alleviate the problem of food safety and environmental pollution.

Socioeconomic development and tele-consumption contribute to the changes in pesticide use in China

“…Furthermore, technological advances can affect the intensity of pesticide use. As the utilization of pesticides increases, the use of pesticides will decrease (Li et al 2020). Additionally, farmers mostly rely on empirical knowledge to use pesticides, resulting in excessive use of pesticides (Dasgupta et al 2007;Zhang et al 2015).…”

Biodegradable and Light-Responsive Polymeric Nanoparticles for Environmentally Safe Herbicide Delivery

“…Stimuli-responsive polymers, which can display a sharp change of chemical or physical properties after the treatment of stimuli, were broadly used to encapsulate pesticides. , Many stimuli-responsive controlled-release pesticide systems were developed based on abiotic and biotic stimuli, such as light, − temperature, , pH, − reactive oxygen species (ROS), redox, , and enzymes. − Among them, light-cleavable polymers attract growing attention because light provides a possible platform for achieving drug release in a remote and spatiotemporal controlled way by facilely adjusting the energy, wavelength, and site of irradiation. − Light-responsive controlled-release pesticide systems hold great potential in agricultural fields because there is abundant sunlight irradiation in open lands, which is clean and sustainable ,− Ding et al developed an amphiphilic polymer–pesticide conjugate that 2,4-D was covalently conjugated with water-soluble PEG by a photolabile o -nitrobenzyl group as a linker.…”

“…Stimuli-responsive polymers, which can display a sharp change of chemical or physical properties after the treatment of stimuli, were broadly used to encapsulate pesticides. 2,29 Many stimuli-responsive controlled-release pesticide systems were developed based on abiotic and biotic stimuli, such as light, 30−33 temperature, 34,35 pH, 36−38 reactive oxygen species (ROS), 39 redox, 6,40 and enzymes. 41−43 Among them, lightcleavable polymers attract growing attention because light provides a possible platform for achieving drug release in a remote and spatiotemporal controlled way by facilely adjusting the energy, wavelength, and site of irradiation.…”

Rapid Construction of Green Nanopesticide Delivery Systems Using Sophorolipids as Surfactants by Flash Nanoprecipitation

“…These different types of formulations were especially advantageous for significantly reducing the indiscriminate use of conventional pesticide formulations, minimizing the ecotoxicity, and improving the desired target position delivery . Typically, assembled amphiphilic polymers are widely used as vans to deliver highly hydrophobic active ingredients in nanopesticide delivery systems. − Nevertheless, in agriculture, most of these synthetic fossil-based surfactants are considered to be impeditive for large-scale applications due to their nonrenewability, relatively high cost, and often complex synthesis process accomplishment. , …”