ROS-scavenging glyco-nanoplatform for synergistic antibacterial and wound-healing therapy of bacterial keratitis

Abstract

Infectious keratitis is a serious disease originating from a corneal trauma infected with bacteria, which is intractable to heal due to stubborn infection and persistent inflammation featured with high reactive...

A Pilot Study to Evaluate Genipin in Staphylococcus aureus and Pseudomonas aeruginosa Keratitis Models: Modulation of Pro-Inflammatory Cytokines and Matrix Metalloproteinases

“…Corneal local response to infection and bacterial toxins includes an inflammatory process with infiltration of neutrophils, granulocytes, monocytes, and macrophages at the site of infection for pathogen clearance [ 68 , 73 , 74 , 75 ]. This inflammatory response is associated with elevated expression of pro-inflammatory cytokines (TNF-a, IL1b, IL1a, IL6) and the generation of reactive oxygen species that can worsen the injury, alter the normal function of endogenous macrophages and stem cells by avoiding tissue regeneration and ultimately affecting corneal transparency and normal tissue structure-function relationship [ 76 , 77 , 78 , 79 ]. Retarding corneal melting in the setting of infectious keratitis could potentially minimize the risk of corneal ulceration, melting, and perforation.…”

A Ti3C2 MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

“…The DPPH and ABTS assays were performed to evaluate the radical scavenging ability of different scaffolds as they are the most commonly used representative free radicals in laboratory assays. 60,61 As shown in Fig. S2 (ESI †), both PME/PDA and PME/ PDA/MXene scaffolds possessed evident radical scavenging capacities compared with the PME group.…”

Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis

“…Among bacterial pathogens, Staphylococcus aureus ( S.aureus ) is the predominant pathogen inducing keratitis since it is a common inhabitant on ocular surface ( Silva et al, 2019 ; Zhang et al, 2019 ). The cornea of rats infected by S. aureus was therefore widely utilized to perform the experimental keratitis research ( Zhang et al, 2021 ; Zhang et al, 2022b ). At present, BK is commonly administrated with topical eye drops of broad-spectrum antibiotics such as levofloxacin (LVFX), ciprofloxacin and moxifloxacin ( Li et al, 2020a ).…”