Rosai-Dorfman disease masquerading as Uveal Melanoma

Yousef, Yacoub A.; Al‐Hussaini, Maysa; Nazzal, Rashed Mustafa; Abdeen, Ghadeer; Al-Nawaiseh, Ibrahim; Alrawashdeh, Khaleel

doi:10.1016/j.hemonc.2018.05.005

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…[3] Infiltrations of the conjunctiva/subconjunctiva, lacrimal tract, cornea, epibulbar and uveal tract, ciliary body as well as of the optic nerve, have been reported. [21920] In this location, RDD could mimic lymphoma and lacrimal gland tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a diagnostic incisional biopsy is recommended in such before considering enucleation. [19] Radiological features of orbital involvement have been reported in a few cases and characterized by infiltrative soft-tissue mass with variable contrast enhancement. [3] When RDD present as a diffuse infiltrating orbital mass, the radiological differential diagnosis includes orbital pseudotumor, lymphoma, sarcoidosis, lymphangioma, or hemangioma.…”

Section: Discussionmentioning

confidence: 99%

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Orbital Rosai–Dorfman disease: A case report and literature review

Al-Maghrabi

Elnaggar

Alamri

et al. 2019

J Microsc Ultrastruct

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A 53-year-old male presented with dropping of the right eyelid associated with decreased visual acuity for 4 months. He also complained of vertical diplopia especially when looking down. Ophthalmological examination revealed right blepharospasm associated with right hypertropia. There was palpable mass at the inferomedial aspect of the right eye. Magnetic resonance imaging revealed abnormal signal intensity in the right orbit inferior aspect occupying the orbital floor and measured 2.7 cm × 2.5 cm × 1.2 cm and showed enhancement on the postcontrast study. The patient underwent complete excision of the tumor. Histological examination of the mass revealed histiocytic proliferation with emperipolesis, with positive S100, positive CD68, and negative CD1a staining. These histological and immunohistochemical features are consistent with extranodal Rosai–Dorfman disease. There was no complication or recurrence after the complete excision.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Orbital Rosai–Dorfman disease: A case report and literature review

Al-Maghrabi

Elnaggar

Alamri

et al. 2019

J Microsc Ultrastruct

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“…11,15,16 Rosai-Dorfman can present as a masquerading disease, notably for uveal melanoma. 17 While B-scan ultrasonography of uveal melanoma often has typical characteristics consisting of a mushroom shape, low to medium reflectivity, and internal vascularity, in rare cases Rosai-Dorfman may mimic some of these findings. 17 Intraocular manifestations of Rosai-Dorfman remain rare and the best ophthalmic treatment remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…17 While B-scan ultrasonography of uveal melanoma often has typical characteristics consisting of a mushroom shape, low to medium reflectivity, and internal vascularity, in rare cases Rosai-Dorfman may mimic some of these findings. 17 Intraocular manifestations of Rosai-Dorfman remain rare and the best ophthalmic treatment remains unclear. Treatment for orbital disease has included steroids, chemotherapy, surgery, radiation, and interferon.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Choroidal Osteomas in Rosai-Dorfman Disease

Storey

Koo

Berry

2018

Journal of VitreoRetinal Diseases

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Purpose: The purpose of this case report is to describe a case of bilateral choroidal osteomas in Rosai-Dorfman disease, a rare pseudolymphomatous disorder. Methods: A case report was conducted. Results: A middle-aged man with biopsy-proven Rosai-Dorfman disease presented with chronic poor vision of the left eye. Clinical examination showed bilateral white lesions with scalloped edges, and optical coherence tomography revealed hyporeflective choroidal lesions. Ultrasonography confirmed the lesions as choroidal osteomas. The patient was observed and remains stable after 9 months of follow-up. Conclusions: Bilateral choroidal osteomas in the setting of Rosai-Dorfman disease are an uncommon finding. While the best treatment for the disease remains unclear, observation is a reasonable option for stable patients.

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“…Nowadays, the definite diagnosis of RDD depended on pathological examination. Because of the raity of RDD, almost all reports were case reports, more data should be collected for further summarization about clinical features [4,[7][8][9].…”

Section: Clinical Features Of Rddmentioning

confidence: 99%

Untitled

2020

MCR

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Background and Objective: Rosai-Dorfman disease (RDD) are usually misdiagnosed because of rarity and nonspecific clinical and radiological features. The aim of our study is to explore the clinical and imaging characteristics of RDD to improve diagnostic accuracy. Methods: Clinical and imaging data in 10 patients with RDD were retrospectively analyzed. 7 patients were underwent CT scanning and 3 patients were underwent MR examination. Results: 8 (8/10) patients presented with painless enlarged lymph nodes (LNs) or mass. 3 cases were involved with LNs, 5 cases were involved with extra-nodal tissues, and the remaining 2 cases were involved with LNs and extra-nodal tissue simultaneously. In enhanced CT images, enlarged LNs displayed mild or moderate enhancement, and 2 cases showed heterogeneous ring-enhancement. MR features of 3 patients with extra-nodal RDD, 2 cases showed a mass located in the subcutaneous and anterior abdominal wall respectively, and 1 case showed an intracranial mass. Besides, all lesions showed high signal foci on DWI images, and were characterized by marked heterogeneous enhancement with blurred edge. The dural/fascia tail sign and dilated blood vessels could be seen around all the lesions on enhanced MRI. Radiological features of 2 cases with LN and extranodal tissue involved, one case presented with the swelling and thickening of pharyngeal lymphoid ring and nasopharynx, meanwhile with enlarged LNs in bilateral submandibular area, neck and abdominal cavity, and also companied with osteolytic lesion in right proximal humerus. All these LNs displayed mild and moderate enhancement on CT images. Another case showed enlarged LNs in bilateral neck accompanied with soft tissue mass in the sinuses. Conclusions: RDD occurred commonly in young and middle-aged men and presented with painless enlarged LNs or mass.RDD had a huge diversity of imaging findings, which varied with different location. The radiological features, such as small patches of high signal foci in the masses on DWI images, heterogeneous enhancement and blood vessels around the masses, are helpful in diagnosis of extranodal RDD.

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Rosai-Dorfman disease masquerading as Uveal Melanoma

Abstract: RDD can present as an intraocular mass that mimics ciliary body melanoma. This case emphasizes the importance of diagnostic biopsy before considering the final therapy in unclear cases, mainly when associated with unusual systemic features like lymphadenopathy.

Cited by 10 publications

References 6 publications

Orbital Rosai–Dorfman disease: A case report and literature review

Orbital Rosai–Dorfman disease: A case report and literature review

Bilateral Choroidal Osteomas in Rosai-Dorfman Disease

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