Roseomics: a blank slate

Abstract

Recent technological advances have led to an explosion in the system-wide profiling of biological processes in the study of herpesvirus biology, herein referred to as “-omics”. In many cases these approaches have revealed novel virus-induced changes to host cell biology that can be targeted with new antiviral therapeutics. Despite these successes, -omics approaches are not widely applied in the study of roseoloviruses. Here we describe examples of how -omics studies have shaped our understanding of herpesvirus biology, and discuss how these approaches might be used to identify host and viral factors that mediate roseolovirus pathogenesis.

Roseoloviruses: unmet needs and research priorities

“…Roseoloviruses: time for action (Robert C. Gallo, Institute for Human Virology) Roseolovirus impacts and needs: a community perspective (Kristin Loomis, Human Herpesvirus 6 Foundation) Clinical impact of primary infections with roseoloviruses (Mary Caserta, University of Rochester) [2] Roseoloviruses in immune compromised patients: impacts and prospects for clinical trials (Danielle Zerr, University of Washington) [3] Neurologic complications of roseoloviruses in immune competent children (Leon Epstein, Northwestern University) [2] The path to therapeutics for roseolovirus infections (Richard J. Whitley, University of Alabama at Birmingham) [4] Diagnosis of roseolovirus infections: what we know we don't know (Keith Jerome, University of Washington) [5] Roseoloviruses: a treasure trove of immune modulators (Amy Hudson, Medical College of Wisconsin) [6] Chromosomally integrated HHV-6: impacts on virus, cell, and organismal biology (Louis Flamand, Université Laval) [7] Animal Models (Paolo Lusso, National Institute of Allergy and Infectious Diseases) [8] Roseomics: a blank slate (Eain Murphy, Cleveland Clinic) [9] a References are provided for review articles prepared by the speakers and their colleagues for inclusion in this issue of Current Opinions in Virology. The special issue contains additional related articles [10][11][12].…”