Roseophilin-inspired derivatives as transmembrane anion carriers

Díaz-Cabrera, Sandra; Carreira-Barral, Israel; Garcı́a-Valverde, Marı́a; Quesada, Roberto

doi:10.1080/10610278.2022.2099277

Cited by 2 publications

(4 citation statements)

References 32 publications

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“…The activity of this type of compounds was shown to be quite sensitive to subtle structural changes, and most of the designs explored afforded highly active transporters, but only with the right substituents (see Section 3.5 for an extended discussion on the most efficient transporters). In contrast to all the changes explored in the peripheral groups, a recent study shows that the central pyrrole ring is crucial for the transport activity of prodiginines and tambjamines, since its substitution by furan rings afforded poor transporters [83] …”

Section: Overview Of Synthetic Bicarbonate Transportersmentioning

confidence: 95%

“…In contrast to all the changes explored in the peripheral groups, a recent study shows that the central pyrrole ring is crucial for the transport activity of prodiginines and tambjamines, since its substitution by furan rings afforded poor transporters. [83] Schmitzer and co-workers have reported the cationic transporters 32-34, which were studied as bromide, bistriflimide or hexafluorophosphate salts. [84][85][86] While compounds 32 a-d and 33 a-b contain cationic imidazolium rings, steroid-based transporters 34 a-b contain secondary ammonium groups.…”

Section: Cationic Transportersmentioning

confidence: 99%

Section: Overview Of Synthetic Bicarbonate Transportersmentioning

confidence: 99%

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Transmembrane Transport of Bicarbonate by Anion Receptors

Martínez‐Crespo

Valkenier

2022

ChemPlusChem

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The development of synthetic anion transporters is motivated by their potential application as treatment for diseases that originate from deficient anion transport by natural proteins. Transport of bicarbonate is important for crucial biological functions such as respiration and digestion. Despite this biological relevance, bicarbonate transport has not been as widely studied as chloride transport. Herein we present an overview of the synthetic receptors that have been studied as bicarbonate transporters, together with the different assays used to perform transport studies in large unilamellar vesicles. We highlight the most active transporters and comment on the nature of the functional groups present in active and inactive compounds. We also address recent mechanistic studies that have revealed different processes that can lead to net transport of bicarbonate, as well as studies reported in cells and tissues, and comment on the key challenges for the further development of bicarbonate transporters.

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Section: Overview Of Synthetic Bicarbonate Transportersmentioning

confidence: 95%

Section: Cationic Transportersmentioning

confidence: 99%

See 1 more Smart Citation

Transmembrane Transport of Bicarbonate by Anion Receptors

Martínez‐Crespo

Valkenier

2022

ChemPlusChem

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show abstract

“…In contrast to all the changes explored in the peripheral groups, a recent study shows that the central pyrrole ring is crucial for the transport activity of prodiginines and tambjamines, since its substitution by furan rings afforded poor transporters. 80 Schmitzer and co-workers have reported the cationic transporters 32-34, which were studied as bromide, bistriflimide or hexafluorophosphate salts. [81][82][83] While compounds 32a-d and 33a-b contain cationic imidazolium rings, steroid-based transporters 34a-b contain secondary ammonium groups.…”

Section: Cationic Transportersmentioning

confidence: 99%

Transmembrane transport of bicarbonate by anion receptors

Martínez‐Crespo

Valkenier

2022

Preprint

View full text Add to dashboard Cite

The development of synthetic anion transporters is motivated by their potential application as treatment for diseases that originate from deficient anion transport by natural proteins. Transport of bicarbonate is important for crucial biological functions such as respiration and digestion. Despite this biological relevance, bicarbonate transport has not been as widely studied as chloride transport. Herein we present an overview of the synthetic receptors that have been studied as bicarbonate transporters, together with the different assays used to perform transport studies in large unilamellar vesicles. We highlight the most active transporters and comment on the nature of the functional groups present in active and inactive compounds. We also address recent mechanistic studies that have revealed different processes that can lead to net transport of bicarbonate, as well as studies reported in cells and tissues and comment on the key challenges for the further development of bicarbonate transporters.

show abstract

Roseophilin-inspired derivatives as transmembrane anion carriers

Cited by 2 publications

References 32 publications

Transmembrane Transport of Bicarbonate by Anion Receptors

Transmembrane Transport of Bicarbonate by Anion Receptors

Transmembrane transport of bicarbonate by anion receptors

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