Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in d -galactosamine ( d -GalN)-sensitized mice

Osakabe, Naomi; Yasuda, Akiko; Natsume, Mitsutaka; Sanbongi, Chiaki; Kato, Yoji; Osawa, Toshihiko; Yoshikawa, Toshikazu

doi:10.1016/s0891-5849(02)00970-x

Cited by 168 publications

(108 citation statements)

References 43 publications

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“…Recruitment of inflammatory cells, including eosinophils, mast cells, basophils, and T cells, results in further release of histamine and leukotrienes, as well as in the release of other compounds including proinflammatory cytokines, COX-2, and chemokines, sustaining the allergic response and promoting the late phase response (Fuentes-Beltrán et al, 2009;Fukui et al, 2009). In previous studies, polyphenolic phytochemicals including rosmarinic acid have been shown to inhibit IgE response (Makio et al, 2001;Tachibana et al, 2001) and inflammation characterized by polymorphonuclear leukocytes (eosinophils, and neutrophils) infiltration (Osakabe et al, 2002;Sanbongi et al, 2003). Glucocorticosteroid (GC) is the most effective drug for AR.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

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Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

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“…P. vulgaris is known as selfheal; contains several active components, including oleanolic acid, betulinic acid, ursolic acid, flavonoids and rosmarinic acid [2][3][4]. Some pharmacological activities such as the immunmodulatory effect [5,6], anti-viral activity against HSV-1, HSV-2 [7,8], HIV [9,10], antioxidant activity [1,11] and anti hyperglycemic action [8] were confirmed. In spite of its traditional uses as an antiseptic agent for treatment of wounds and sore throat, there are a few literatures on its antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial activity of Prunella vulgaris extracts

Mahboubi¹,

Mahboubi

Kazempour³

2015

Herba Polonica

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S u m m a r yPrunella vulgaris (Labiatae family) or self-heal is traditionally used for different ailments such as eye pain and inflammation, headache, dizziness, sore throat and wound healing. Total phenolic and total flavonoid contents of extracts (methanol, ethanol and aqueous) were determined by a spectrophotometer. The antimicrobial activity was evaluated by micro broth dilution assay. The total phenolic content of P. vulgaris extracts were higher in aqueous extract (156.5 mg GAC/g) followed by ethanol extract and methanol extract. The TFC content of P. vulgaris methanol extract (82.8 mg QE/g) was higher than ethanol extract (22.7 mg QE/g) and aqueous extract (16.2 mg QE/g). The antimicrobial activity of methanol or ethanol extracts was higher than aqueous extract from P. vulgaris. The sensitivity of microorganisms to different extracts is related to type of pathogens. There is no positive relation between total phenolic content and its antimicrobial activity. Prunella vulgaris ethanolic extract as a source of phenolic and flavonoid contents can be used as an antimicrobial agent.

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“…Rosmarinic acid (RA), one of the major phenolics, suppresses lipoperoxidation (Laranjinha et al, 1994), scavenges superoxide radicals (Osakabe et al, 2002), and exhibits anti-inflammatory (Osakabe et al, 2004) and antioxidant (Psotova et al, 2003) bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Changes in bioactive components related to the harvest time from the spicas ofPrunella vulgaris

Chen¹,

Q²,

Zhu³

et al. 2012

Pharmaceutical Biology

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Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in d -galactosamine ( d -GalN)-sensitized mice

Cited by 168 publications

References 43 publications

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

The antimicrobial activity of Prunella vulgaris extracts

Changes in bioactive components related to the harvest time from the spicas ofPrunella vulgaris

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