Rosmarinic acid administration attenuates diabetes-induced vascular dysfunction of the rat aorta

Abstract

Rosmarinic acid protected aortic endothelial function and ultrastructure against diabetes-induced damage. Both antioxidant and anti-inflammatory effects of rosmarinic acid seemed to participate in the mechanism of this protection.

Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats

“…anti-allodynic effects of RA may be due to the ameliorative effect of RA on vascular dysfunction in diabetic rats (Sotnikova et al, 2013). Vascular dysfunction may be involved in the pathophysiology of diabetic neuropathy (Murakami et al, 2013), so the anti-vascular dysfunction effect of RA may also play to some extent to the beneficial effects of RA in the present work.…”

“…Interestingly, the anti-hyperalgesic and anti-allodynic effects of RA in diabetic animals were not accompanied by changing the plasma glucose level, so the effect of RA on the pain threshold of diabetic rats may not be the result of changing this factor. It has been also reported in previous published works that RA administration in diabetic rats failed to alter hyperglycemia of diabetic rats even at doses higher than used here so it seems that the neuroprotective effects of RA are independent of changing blood glucose of diabetic rats (Jiang et al, 2012;Luan et al, 2013;Sotnikova et al, 2013).…”

“…It has been shown that the 8-weeks of streptozotocin diabetes in rats are accompanied by oxidative stress and inflammatory processes (Sotnikova et al, 2013). Since oxidative stress and inflammation may be involved in the diabetic neuropathy, the antioxidant and anti-inflammatory effects of RA may participate in the observed effects.…”

“…RA has some beneficial bioactivities in diabetes such as neuroprotective, anti-diabetic nephropathy, and vascular dysfunction effects (Luan et al, 2013;Jiang et al, 2012;Sotnikova et al, 2013). Since there are no experimental studies on the effects of RA on diabetic neuropathy, we investigated the effect of long-term oral RA administration on experimental models of thermal/chemical hyperalgesia and tactile allodynia in streptozotocin-induced diabetic rats.…”

An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

“…Vitamin E supplementation has also been reported to possess beneficial role in preventing and delaying the onset of cardiovascular events in diabetic patients by reducing lipoproteins and reducing the activity of oxidative stress enzymes such as glutathione peroxidise GSH-Px) and glutathione S-transferase (GST) [93,94]. Another natural antioxidant, Rosmarinic acid, has been found to protect aortic endothelial function and structural alterations in diabetic rats by through its anti-inflammatory and antioxidant properties [95].…”