Rosmarinic Acid Ameliorates Deltamethrin Induced Hepatotoxicity and Nephrotoxicity

Abstract

Deltamethrin (DM) is an insecticide and is widely used around the world. Rosmarinic acid (RA) is found in herbs and spices in the Lamiaceae (mint) family and has antioxidant, anti-inflammatory and anti-apoptotic effects. We aimed to examine the protective efficacy of Rosmarinic acid in preventing the toxic effects of Deltamethrin. 
 A total of 28 male rats were used in this study. Group 1: Control group, Group 2: RA group, RA was given 20 mg/kg peroral (p.o.) for 7 days, Group 3: DM group, 35 mg/kg/dose of DM was given 24 hours before sacrification as a single dose by gavage, Group 4: RA+ DM group. RA was given for 7 days, at the end of the 7th day, a single dose of 35 mg/kg DM was given and the animals were sacrificed after 24 hours. 
 BUN, creatinine, AST and ALT values of the RA+DM group were lower than the DM group. Serum TAS and TOS values were higher in the DM group compared to the RA+DM group. The damage scores of the DM group were higher than those of the RA+DM group.
 Rosmarinic acid has been shown to have positive effects in the treatment of deltamethrin-induced nephrotoxicity and hepatotoxicity.