Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease

Stansbury, Jill; Saunders, Paul A.; Winston, David; Zampieron, Eugene R.

doi:10.14200/jrm.2012.1.1013

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…3 M phosphate buffer with different pHs. [2][3][4][5][6][7] Other conditions were the same as Figure 2. Inset shows the relationship between peak potential and pH for peak 1 (•) and peak 2 (•).…”

Section: Resultsmentioning

confidence: 99%

“…The caffeic acid part is formed only from phenylalanine and the 3,4-dihydroxyphenyllactic acid only from tyrosine. 2 RA has a multitude of interesting biological properties such as treating autoimmune disease 3 and inhibiting HIV-1 virus. 4 It is also antiinvasive, 5 anti-hepatitis, 6 anticancer, 7 antibacterial, 8,9 antiviral, 10 antimutagen, 11 anti-inflammatory, 12,13 one of the most efficient natural antioxidants and widely used in the cosmetic formulations and food industry.…”

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confidence: 99%

“…Figure 7. SWSV of RA at the surface of ChiCNTPE/DNA obtained in 0.3 M phosphate buffer with different pHs [2][3][4][5][6][7]. Other conditions were the same as Figure2.…”

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confidence: 99%

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Voltammetric Determination of Rosmarinic Acid on Chitosan/Carbon Nanotube Composite-Modified Carbon Paste Electrode Covered with DNA

Mohamadi

Mostafavi

Torkzadeh‐Mahani

2015

J. Electrochem. Soc.

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The electrochemical behavior of rosmarinic acid at the surface of a DNA-coated electrode was investigated using square-wave stripping voltammetry. The voltammetric studies showed that rosmarinic acid is oxidized in two successive pH-dependent steps each with the transfer of two electrons and two protons. These oxidations correspond to two electroactive catechol groups. Moreover, strong interaction between the immobilized DNA and rosmarinic acid accumulates rosmarinic acid on the electrode surface resulting in an efficient preconcentration leading to high sensitivity of the sensor for rosmarinic acid determination. Several experimental parameters affecting the sensor response were optimized. Under optimized conditions, a linear concentration range of 0.040-1.5 μM with a detection limit of 0.014 μM was obtained. The proposed method was successfully applied to the analysis of a rosemary extract. The obtained data was in good agreement to that obtained from HPLC analysis.

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Section: Resultsmentioning

confidence: 99%

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Voltammetric Determination of Rosmarinic Acid on Chitosan/Carbon Nanotube Composite-Modified Carbon Paste Electrode Covered with DNA

Mohamadi

Mostafavi

Torkzadeh‐Mahani

2015

J. Electrochem. Soc.

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“…spp., inhibits the formation of pro-inflammatory mediators, lipoxygenase, and 5-HETE also expresses antiphlogistic activity with no relative activity upon prostaglandin synthesis (81,82). Moreover, rosmarinic acid binds to T-cells and blocks signaling pathways to the nucleus resulting in cytokine release inhibition like IL-1 that would be used in treating autoimmune diseases (83). The rosmarinic acid quantity in the selected plant species was in the range of 1.2 -36.6 mg.g -1 air-dry matter in the aerial parts and 1.3 -27.0 mg.g -1 air-dried matter in the roots.…”

Section: Phytochemicals and Anti-inflammatory Properties Of Symphytum...mentioning

confidence: 99%

Anti-inflammatory Properties of the Genus Symphytum L.: A Review

2022

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: The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine’s and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. The papers with the English language were gathered from 2000 to 2021. This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The Symphytum genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action.

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“…Whatʼs more, other active constituents are also bioactive. Tanshinone I has activity in the treatment of angina pectoris [12], dihydrotanshinone I shows an inhibitory effect on the induction of apoptosis and action of DNA topoisomerase I [13,14], and rosmarinic acid also has shown biological activities, such as protection of the liver, and inhibiting antitumor, HIV-I, antihepatitis, blood clots, and anti-inflammation [15,16]. In recent years, there has been a mounting demand for S. miltiorrhiza because of its potent Abstract !…”

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Spaceflight Environment-Induced Variation in Root Yield and Active Constituents of Salvia miltiorrhiza

Peng

Wang

et al. 2014

Planta Med

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Salvia miltiorrhiza is a significant source of bioactive compounds providing human health effects. Here, we surveyed root yield and the active constituents' divergences of second generation S. miltiorrhiza (SP2) responding to a spaceflight environment. High-performance liquid chromatography was conducted for the comprehensive constituents' characterizations of 28 SP2 lines (224 individuals) and the ground control (eight individuals). The results showed that the mean fresh and dry weight of roots ranged from 116 to 172 g and 25 to 119 g, respectively, in SP2 lines. In addition, the mean contents of four tanshinone compounds (tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone I) of 28 SP2 lines varied from 0.32 to 1.04 mg · g(-1), 0.47 to 2.39 mg · g(-1), 0.25 to 1.60 mg · g(-1), and 0.53 to 1.67 mg · g(-1), respectively. Except for salvianolic acid B, which varied drastically from 72 % to 201 % of the ground control treatment, the other six phenolic acid contents of the 28 SP2 lines all increased after spaceflight. Principal component analysis was performed to obtain an overview of the distribution of all samples, and score plots clearly separated the SP2 accessions from ground controls. Moreover, a positive relationship was observed between tanshinone I and tanshinone IIA (r = 0.790, p < 0.01), and rosmarinic acid was positively correlated with salvianolic acid B (r = 0.728, p < 0.01). In conclusion, this study demonstrated that a spaceflight environment induced SP2 accessions remarkably in the variation of root yield and active constituent content.

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Rosmarinic Acid as a Novel Agent in the Treatment of Autoimmune Disease

Cited by 3 publications

References 11 publications

Voltammetric Determination of Rosmarinic Acid on Chitosan/Carbon Nanotube Composite-Modified Carbon Paste Electrode Covered with DNA

Voltammetric Determination of Rosmarinic Acid on Chitosan/Carbon Nanotube Composite-Modified Carbon Paste Electrode Covered with DNA

Anti-inflammatory Properties of the Genus Symphytum L.: A Review

Spaceflight Environment-Induced Variation in Root Yield and Active Constituents of Salvia miltiorrhiza

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