Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling

Cui, Haiying; Zhang, Xiangjian; Yang, Yi; Zhang, Cong; Zhu, Changlian; Miao, Jiangyong; Chen, Rong

doi:10.4103/1673-5374.241463

Cited by 71 publications

(16 citation statements)

References 55 publications

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“…It helps prevent cell damage caused by free radicals. Rosmarinic acid has shown to have anti-oxidative and anti-apoptotic effects against ischemia/reperfusion damage in brain tissue via signaling factor 2 and heme oxygenase-1 associated with nuclear erythroid factor 2 32 . Rosmarinic acid in ovariectomized rats was found to be effective in the oxidative damage parameters in the serum.…”

Section: ■ Discussionmentioning

confidence: 99%

Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

Değer

Çavuş

2020

Acta Cir. Bras.

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To investigate the protective effect of rosmarinic acid (RA) in ovarian ischemia/reperfusion injury using biochemical, histopathological, and immunohistochemical methods. Methods: Wistar female rats (n = 32) were randomly divided into four groups: control, ischemia, ischemia-reperfusion, and ischemia-reperfusion with RA. Rosmarinic acid was given at a dose of 50 mg/kg by oral gavage three hours after reperfusion. Malondialdehyde (MDA) levels and glutathione peroxidase (GSH-Px) activities were determined in the ovary tissue homogenates for each rat. Results: In the ischemia-reperfusion with RA group, the epithelial cells are regularly regulated at the periphery, and the degenerative changes in preantral and antral follicle cells are reduced. Follicle cells and cells in the corpus luteum showed a decrease in vascular endothelial growth factor (VEGF) expression, while VEGF demonstrated a positive reaction in vascular endothelial cells and stromal cells. The TNF-α expression due to the decreased degenerative effect and inflammation was positive in the macrophage cells. The expression of caspase-3 as an apoptosis change was negative in antral follicle cells and granular cells around the antral follicle. Conclusion: Different doses of RA may be useful in preventing ischemic damage after vascularization, inflammation, and apoptotic development after ischemia/reperfusion.

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Section: ■ Discussionmentioning

confidence: 99%

Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

Değer

Çavuş

2020

Acta Cir. Bras.

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“…Antioxidant[188]Rosmarinic acida. Neuroprotective[189]b. Protective effect against nicotine-induced atherosclerosis[190]c.…”

Section: Introductionmentioning

confidence: 99%

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

2019

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Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservative. R. officinalis L. is constituted by bioactive molecules, the phytocompounds, responsible for implement several pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, antiproliferative, antitumor and protective, inhibitory and attenuating activities. Thus, in vivo and in vitro studies were presented in this Review, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents. In this way, methodology, mechanisms, results, and conclusions were described. The main objective of this study was showing that plant products could be equivalent to the available medicines.

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“…The inhibitor of PI3K/Akt signaling pathway abolished Akt phosphorylation, together with Nrf2 and HO-1 expressions. These results suggested that RA was able to counteract oxidative stress and apoptosis inducing Nrf2/HO-1 pathway through the PI3K/Akt signaling [58].…”

Section: Spice Bioactive Compoundsmentioning

confidence: 78%

Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?

Gugliandolo

Bramantı

Mazzon

2020

IJMS

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Stroke represents one of the main causes of disability and death worldwide. The pathological subtypes of stroke are ischemic stroke, the most frequent, and hemorrhagic stroke. Nrf2 is a transcription factor that regulates redox homeostasis. In stress conditions, Nrf2 translocates inside the nucleus and induces the transcription of enzymes involved in counteracting oxidative stress, endobiotic and xenobiotic metabolism, regulators of inflammation, and others. Different natural compounds, including food and plant-derived components, were shown to be able to activate Nrf2, mediating an antioxidant response. Some of these compounds were tested in stroke experimental models showing several beneficial actions. In this review, we focused on the studies that evidenced the positive effects of natural bioactive compounds in stroke experimental models through the activation of Nrf2 pathway. Interestingly, different natural compounds can activate Nrf2 through multiple pathways, inducing a strong antioxidant response associated with the beneficial effects against stroke. According to several studies, the combination of different bioactive compounds can lead to a better neuroprotection. In conclusion, natural bioactive compounds may represent new therapeutic strategies against stroke.

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Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling

Cited by 71 publications

References 55 publications

Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?

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