Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats

Venkatachalam, Karthikkumar; Gunasekaran, S.; Viswanathan, P. N.; Nalini, Namasivayam

doi:10.1515/jbcpp-2014-0044

Cited by 26 publications

(15 citation statements)

References 24 publications

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“…Doolaege, et al reported that 64.3 mg/kg (193.43 mM) CA orally administered to rats resulted in a plasma concentration of 0.015 mg/mL (45.12 μM) [116]. Another study reported that ingestion of 360 mg/kg/day RA after 8 weeks resulted in a plasma concentration of 1.1 μM [117]. The reported plasma concentrations of CA, carnosol and their metabolites were in the micromolar range indicating that absorption and bioavailability are likely not barriers for these components of RE [114,115,118].…”

Section: Dosage and Bioavailabilitymentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

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Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. The exploration into natural products offers great opportunity to evaluate new anticancer agents as well as understand novel and potentially relevant mechanisms of action. Rosemary extract has been reported to have antioxidant, anti-inflammatory, antidiabetic and anticancer properties. Rosemary extract contains many polyphenols with carnosic acid and rosmarinic acid found in highest concentrations. The present review summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of rosemary extract and the rosemary extract polyphenols carnosic acid and rosmarinic acid, and their effects on key signaling molecules.

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Section: Dosage and Bioavailabilitymentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

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“…Recent studies have revealed that RA possessed antioxidant, anti-inflammatory, and anti-angiogenic effects [34]. Furthermore, accumulating evidence indicates that RA has anti-tumor effects by inhibiting tumor cell growth [5]. Our previous studies showed that RA had anti-tumor effects in the H22 -xenograft models with little toxicity effects and the mechanism involved inhibition of inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment [6].…”

Section: Introductionmentioning

confidence: 99%

Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis inH22tumor-bearing mice

Cao¹,

Wei³

et al. 2019

Korean J Physiol Pharmacol

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Rosmarinic acid (RA) is a natural polyphenolic compound that exists in many medicinal species of Boraginaceae and Lamiaceae. The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and NF-κB p65 pathway in the tumor microenvironment. However, its molecular mechanisms of immunoregulation and pro-apoptotic effect in HCC have not been fully explored. In the present study, RA at 75, 150, and 300 mg/kg was given to H22 tumor-bearing mice via gavage once a day for 10 days. The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4+/CD8+ and the secretion of interleukin (IL)-2 and interferon-γ, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2. The underlying mechanisms involved regulation of immune response and induction of HCC cell apoptosis. These results may provide a more comprehensive perspective to clarify the anti-tumor mechanism of RA in HCC.

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“…The phase II enzymes, including glutathione S-transferase (GST) and DT-diaphorase (DTD) detoxify the electrophilic intermediates [ 17 , 18 ]. The quantitative evaluation of argyrophilic nucleolar organizing regions (AgNORs) determines the rate of cell proliferation and their numbers can reflect the prognosis of colon cancer [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet

et al. 2018

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Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats

Abstract: The above findings clearly underline the chemopreventive efficacy of RA against DMH-induced colon carcinogenesis.

Cited by 26 publications

References 24 publications

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis inH22tumor-bearing mice

Orientin, a flavanoid, mitigates 1, 2 dimethylhydrazine-induced colorectal lesions in Wistar rats fed a high-fat diet

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