2015
DOI: 10.1016/j.freeradbiomed.2015.04.021
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Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea

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Cited by 107 publications
(89 citation statements)
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“…Since PI3K/AKT/Bcl-2 pathway and Nrf2/HO-1 pathway play pivotal roles in cell growth/survival [29], [30], [31] and adaptive oxidative response [32], [33], [34], we hypothesized that PI3K/AKT/Bcl-2 and Nrf2/HO-1 signaling pathways were involved in the hormetic effect induced by low dose BBR. We examined the phosphorylated and total protein levels of PI3K, AKT, Bcl-2, HO-1 and Nrf2 treated with low dose BBR in PC12 cells by Western blotting assay.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Since PI3K/AKT/Bcl-2 pathway and Nrf2/HO-1 pathway play pivotal roles in cell growth/survival [29], [30], [31] and adaptive oxidative response [32], [33], [34], we hypothesized that PI3K/AKT/Bcl-2 and Nrf2/HO-1 signaling pathways were involved in the hormetic effect induced by low dose BBR. We examined the phosphorylated and total protein levels of PI3K, AKT, Bcl-2, HO-1 and Nrf2 treated with low dose BBR in PC12 cells by Western blotting assay.…”
Section: Resultsmentioning
confidence: 99%
“…Increasing evidence suggests that many phytochemicals can activate pathways that prevent or reverse oxidative injury [55]. The Nrf2/HO-1 signaling pathway is crucial for neuroprotection against oxidative stress [32], [33], [34] and involved in the process of hormesis [36], [56], [57], [58]. Nrf2 is a stress-responsive transcriptional factor and an important effector protecting cells from oxidative injury, particularly neurodegenerative diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the placenta may not be the primary organ involved in HO-1 secretion during pregnancy. HO-1 has previously been detected in human skin fibroblasts [24], tracheal smooth muscle cells [25], kidneys [26], human adipocytes [27], human vascular endothelium [28], a myelodysplastic syndrome cell line (SKM-1) [29], murine intestinal epithelial cells [30], glomeruli [31], and rat cochlea [32]. HO-1 is predominantly expressed in mammalian cells and tissues, and it is synthesized as a protective response to injury [33].…”
Section: Discussionmentioning
confidence: 99%
“…However, the ameliorative effects of antioxidants for the treatment of structural and functional noise stress-induced pathologies in the auditory pathway is imperative and have been reported: compounds such as mannitol [47], salicylates or vitamins A, C and E [48], Nacetylcysteine [49], trolox [50], acetyl-l-carnitine combined with N-acetylcysteine [51] and Ocimum sanctum-a medicinal herb popularly known as basil, attenuates cochlear oxidative damage following hearing loss [52]. Fetoni et al [53] reported that NIHL can be reversed by treatment with a natural antioxidant, CoQ10, which prevents cochlear oxidative stress through the decrease in O 2 ‱− production and lipid peroxidation.…”
Section: Role Of Antioxidants In Ameliorating Noise Stressmentioning
confidence: 99%
“…The irreversible hearing loss induced by exposure of adult mice to 110 dB of noise for 1 h was entirely prevented after the treatment with this compound. Rosmarinic acid, a polyphenol compound, commonly derived from culinary herbs, was able to mitigate the auditory function and assuage the loss of cochlear hair cells damaged by noise exposure, and also attenuated the noise-induced increase in lipid peroxidation and O 2 ‱− production [48]. The phenolic compound orientin, abundant in millet and juice of passion fruit, reduces brain oxidative stress markers and increases activities of antioxidant enzymes.…”
Section: Role Of Antioxidants In Ameliorating Noise Stressmentioning
confidence: 99%