Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

Abstract

The rosemary plant, Rosmarinus officinalis L., one of the main members of the Lamiaceae family, is currently one of the most promising herbal medicines due to its pharmaceutical properties. This research aimed to evaluate the antioxidant role of Rosmarinus officinalis and its bioactive compounds on the skin, with a focus on the newly emerging molecular mechanisms involved, providing extensive scientific evidence of its anti-inflammatory, antimicrobial, wound-healing and anticancer activity in dermatological practice. The search was conducted on articles concerning in vitro and in vivo studies in both animals and humans. The results obtained confirm the antioxidant role of R. officinalis. This assumption derives the possibility of using R. officinalis or its bioactive elements for the treatment of inflammatory and infectious skin pathologies. However, although the use of rosemary in the treatment of skin diseases represents a fascinating line of research, future perspectives still require large and controlled clinical trials in order to definitively elucidate the real impact of this plant and its components in clinical practice.

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities

“…Rosmarinic acid, a natural antioxidant found in essential oils, is commonly used in skin anti-aging formulations and cooking oils to reduce oxidative stress. In this study, rosmarinic acid-capped AgNPs could have significant applications as drug ingredients for the preparation of antioxidant nanoformulations [ 127 ]. The capping of AgNPs with rosmarinic acid enhances their antioxidant activity and provides a natural and sustainable source of antioxidant agents.…”

Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders

“…For this purpose, multiple compounds were examined; among these, rosemary, a medicinal plant renowned for its potential anticancer, antioxidant, and anti-inflammatory actions, as a result of the interplay between the plant’s bioactive constituents and the molecular pathways that control inflammatory processes and redox balance [ 198 , 199 , 200 ]; quercetin, a flavonoid compound found in fruits and vegetables, that executes numerous beneficial tasks by performing as an anticarcinogenic, antioxidant, anti-inflammatory, antidiabetic, and antimicrobial [ 201 ]—its capacities modify cell cycle progression, foster apoptosis, limit cell proliferation, slow the spread of metastases, and inhibit angiogenesis represent the mechanisms by which it exerts its antitumor action, observed both in vitro and in vivo [ 202 , 203 ]. Another polyphenol, curcumin, derived from the rhizomes of Curcuma longa, has demonstrated a wide range of therapeutic advantages towards oxidative damage, metabolic syndrome, obesity, neurological illnesses, and various malignancies.…”

New Insights into Cutaneous Asepsis: Synergism between Pfaffia and Rosemary Extracts

“…Several Gram-positive bacteria, resident human flora, have been identified as opportunistic bacteria responsible for healthcare-associated infections. Among these bacteria, three appear as very important: (i) Staphylococcus aureus , (ii) Staphylococcus epidermidis , and (iii) Cutibacterium acnes also known as Proprionibacterium acnes [ 5 , 6 ]. The Staphylococcus genus stands out due to the number of clinical isolates resistant to oxacillin, exhibiting a frightening 81.33% rate of resistance [ 1 ].…”

“…In this scenario, there is a need to search for new, effective, safe, and low-cost alternatives. Phytotherapy is a field of alternative medicine that uses plants to treat diverse diseases, and it is becoming more common in modern medicine because of its antimicrobial action and biocompatibility; for example, Rosmarinus officinalis , which is popularly known as rosemary, has phytocompounds that have several pharmacological effects, including antimicrobial, anti-inflammatory, and antioxidant effects [ 5 , 13 , 14 , 15 ]. Additionally, Pfaffia paniculata , which is a plant native to the Neotropics known as Brazilian ginseng, has antimicrobial, anti-inflammatory, anticancer and regenerative properties [ 16 ].…”