Rosuvastatin Treatment is Associated with a Decrease of Serum Oxidised Low-Density Lipoprotein/Beta2-Glycoprotein I Complex Concentration in Type 2 Diabetes

Ortiz-Cadenas, Alfredo; Torre, Ignacio García-De La; Nava, Arnulfo; Oregon-Miranda, A.; Batuca, Joana R.; Kojima, Kensuke; Lopez, Luis R.; Matsuura, Eiji

doi:10.1177/1474651410388057

Cited by 11 publications

(15 citation statements)

References 42 publications

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“…ELISA for murine plasma oxLDL/β2GPI complex was prepared in-house as per method of Ames et al. (2010) [ 35 ] and Shen et al. (2011) [ 36 ] with slight modifications.…”

Section: Methodsmentioning

confidence: 99%

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

Xian

Kobayashi

Shen

et al. 2020

Heliyon

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Oxidative stress, chronic inflammation, dyslipidemia, hyperglycemia, and shear stress (physical effect) are risk factors associated with the pathogenesis of atherosclerosis. Rice bran, a by-product of rice milling process, is known to house polyphenols and vitamins which exhibit potent antioxidant and anti-inflammatory properties. Through recent emerging knowledge of rice bran in health and wellness, the present study was aimed to assess the ameliorative effects of rice bran extracts (RBE) derived from Japanese colored rice varieties in modulating risk factors of atherosclerosis via in vitro and in vivo study models. Pre-treatment of lipopolysaccharide (LPS)-stimulated murine J774A.1 macrophage-like cells with RBE alleviated nitric oxide (NO) overproduction and downregulated gene expressions of pro-inflammatory modulators: tumor necrosis factor-α (TNF-α), interleukin (IL)-α (IL-1α), IL-1β, IL-6, and inducible nitric oxide synthase (iNOS). In addition, RBE also significantly attenuated LPS-stimulated protein expressions of iNOS, TNF-α, IL-1α, and IL-6 in J774A.1 macrophage-like cells as compared to non-treated LPS control group. In in vivo , 12 weeks of RBE dietary supplementations significantly reduced (p < 0.05) total cholesterol, triglycerides, and pro-atherogenic oxidized LDL/β2-glycoprotein I (oxLDL/β2GPI) complexes at plasma levels, in high fat diet (HFD) induced low density lipoprotein receptor knockout ( Ldlr −/- ) mice. En face pathological assessments of murine aortas also revealed significant reductions by 38% (p < 0.05) in plaque sizes of RBE-supplemented HFD mice groups as compared to non RBE-supplemented HFD control mice group. Moreover, gene expressions of aortic (iNOS, TNF-α, IL-1β) and hepatic (TNF-α, IL-1α, IL-1β) pro-inflammatory modulators were also downregulated in RBE-supplemented mice groups. Present study has revealed the potent health attributes and application of RBE as a dietary supplement to attenuate risks of inadvertent oxidative damage and chronic inflammation underlying the pathogenesis of atherosclerosis. Intrinsically, present preliminary findings may provide global health prospects for future dietary implementation of RBE in management of atherosclerosis.

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“…ELISA for murine plasma oxLDL/β2GPI complex was prepared in-house as per method of Ames et al. (2010) [ 35 ] and Shen et al. (2011) [ 36 ] with slight modifications.…”

Section: Methodsmentioning

confidence: 99%

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

Xian

Kobayashi

Shen

et al. 2020

Heliyon

Self Cite

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show abstract

“…Since statins are known to lower oxLDL/ β 2GPI, we excluded subjects taking statins [10]. The demographic and clinical characteristics of 100 subjects not taking statins included in the study (27 arterial disease, 25 IVD, and 48 healthy controls) are summarized in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…We enrolled 146 subjects from the vascular surgery outpatient clinic at a tertiary medical center as follows: 61 with arterial disease, 32 with idiopathic venous disease, and 53 healthy controls. Since statins are known to lower oxLDL/ β 2GPI, we excluded subjects taking statins [ 10 ]. The demographic and clinical characteristics of 100 subjects not taking statins included in the study (27 arterial disease, 25 IVD, and 48 healthy controls) are summarized in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

“…Serum oxLDL/ β 2GPI complexes were measured as previously described [ 10 ]. Briefly, IgG2b murine monoclonal antibody (3H3) specific for human β 2GPI was coated onto 96-microwell plates and used to capture oxLDL/ β 2GPI complexes via its reactivity with β 2GPI.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, circulating oxLDL/ β 2GPI complexes in these patients were associated with disease severity and with a 3.5-fold risk of 2-year adverse cardiovascular outcomes [ 9 ]. A recent report clearly demonstrated that rosuvastatin significantly reduced serum levels of oxLDL/ β 2GPI complexes in patients with diabetes, an effect that was independent of LDL levels but likely dependent on an antioxidant inhibition of nitric oxide metabolites [ 10 ]. The presence and significance of anti-oxLDL/ β 2GPI antibodies and oxLDL/ β 2GPI complexes have not been evaluated in nonautoimmune subjects with venous disease.…”

Section: Introductionmentioning

confidence: 99%

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Proatherogenic Oxidized Low-Density Lipoprotein/β2-Glycoprotein I Complexes in Arterial and Venous Disease

Berger

Rockman

Guyer

et al. 2014

Journal of Immunology Research

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OxLDL/β2GPI complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes. We investigate the significance of anti-oxLDL/β2GPI antibodies and oxLDL/β2GPI complexes in patients with arterial and idiopathic venous disease. A cohort of 61 arterial disease patients, 32 idiopathic venous disease patients, and 53 healthy controls was studied. Because statins influence oxLDL/β2GPI, these complexes were analyzed on subjects not taking statins. Arterial and venous groups expressed higher levels of IgG anti-oxLDL/β2GPI antibodies than controls without any other significant clinical association. OxLDL/β2GPI complexes were significantly elevated in arterial (0.69 U/mL, P = 0.004) and venous disease (0.54 U/mL, P = 0.025) than controls (0.39 U/mL). Among arterial diseases, oxLDL/β2GPI was 0.85 U/mL for carotid artery disease, 0.72 U/mL for peripheral artery disease, and 0.52 U/mL for abdominal aortic aneurysm. There was a significant association with male gender, age, hypertension, and history of thrombosis. Subjects with oxLDL/β2GPI above the median (0.25 U/mL) were more likely to have arterial (OR 4.5, P = 0.004) or venous disease (OR 4.1, P = 0.008). Multivariate regression indicated that males (P = 0.021), high cholesterol (P = 0.011), and carotid disease (P = 0.023) were significant predictors of oxLDL/β2GPI. The coexistence of oxLDL/β2GPI in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease.

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Efficacy of oral rosuvastatin intervention on HDL and its associated proteins in men with type 2 diabetes mellitus

et al. 2020

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Rosuvastatin Treatment is Associated with a Decrease of Serum Oxidised Low-Density Lipoprotein/Beta2-Glycoprotein I Complex Concentration in Type 2 Diabetes

Cited by 11 publications

References 42 publications

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

Proatherogenic Oxidized Low-Density Lipoprotein/β2-Glycoprotein I Complexes in Arterial and Venous Disease

Efficacy of oral rosuvastatin intervention on HDL and its associated proteins in men with type 2 diabetes mellitus

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