Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone

Vasconcellos, Luana Marotta Reis de; Elias, Conceição de Maria Vaz; Minhoto, Giovanna Bignoto; Abdala, Julia M A; Andrade, Telmo Macedo de; Araújo, Juliani Caroline Ribeiro de; Gusmão, Suziete B.S.; Viana, Bartolomeu C.; Marciano, Fernanda R.; Lobo, Anderson Oliveira

doi:10.1007/s10856-020-06403-8

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…Bioactive inorganic fillers include isotropic and anisotropic silicates like bioactive glasses and nanoclays or calcium phosphates like hydroxyapatite (HA). , They can provide in situ cross-linking-like effects and add extra functionality to the matrix, for example, mineralization sites. Bioactive glasses are well-recognized materials for bone repair applications due to their ability to form an apatite layer on their surface that promotes a direct bond to the living bone tissue. , Calcium phosphates (HA, α-tricalcium phosphate (α-TCP), β-TCP, tetracalcium phosphate) are each bioceramics that are used extensively in bone tissue engineering applications due to their biocompatibility and osteoconductivity and are therefore frequently added to biodegradable polymers to impart the scaffolds with these favorable properties. − Moreover, HA and other calcium phosphates as well as bioactive glasses act as reinforcing fillers and improve the mechanical properties of the scaffolds not only in the case of weaker hydrogels but also in the case of tougher polymers like PLA or PCL. ,− …”

Section: Biodegradable Polymers: Materials Selectionmentioning

confidence: 99%

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

et al. 2021

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Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors and strategies for designing and creating bioactive scaffolds. However, these defect-specific scaffolds, especially when utilizing degradable polymers as the base material, present processing challenges that are distinct and unique from other classes of materials. The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.

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Section: Biodegradable Polymers: Materials Selectionmentioning

confidence: 99%

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

et al. 2021

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“…In a rat model, a more biocompatible FITC dye was applied, consistent with in vitro labeling, suggesting a general labeling strategy. Considering the water solubility and quick diffusion of these dyes, a small amount of PCL was selected as a slow-degrading polyester to retard the dispersion of the dyes, extending the labeling period. ,, Notably, for both isolated porcine skin and living objects, the MILD microneedle patterns displayed clearly visible signals in a dotted matrix for quite a long time (at least 28 days longer than the most recommended vaccination intervals) without any obvious decay or photobleaching, , demonstrating excellent photostability. During this period, the vaccine protein amount in microneedles exhibited negligible alteration at room temperature, indicating a long-term storage stability of the vaccine in the MILD microneedle system, consistent with the previous study .…”

Section: Discussionmentioning

confidence: 99%

Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage

Fan

et al. 2022

ACS Nano

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The key to controlling the spread of the coronavirus disease 2019 (COVID-19) and reducing mortality is highly dependent on the safe and effective use of vaccines for the general population. Current COVID-19 vaccination practices (intramuscular injection of solution-based vaccines) are limited by heavy reliance on medical professionals, poor compliance, and laborious vaccination recording procedures, resulting in a waste of health resources and low vaccination coverage, etc. In this study, we developed a smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle platform for the effective and convenient delivery of multidose COVID-19 vaccines and decentralized vaccine information storage. The mushroom-like structure allows the MILD system to be easily pressed into the skin and detached from the patch base, acting as a “tattoo” to record the vaccine counts in situ without any storage equipment, offering quick accessibility and effortless readout, saving a great deal of valuable time and energy for both patients and health professionals. After loading inactivated SARS-CoV-2 virus-based vaccines, MILD system induced a high level of antibodies against the SARS-CoV-2 receptor-binding domain (RBD) in vivo without eliciting systemic toxicity and local damage. Collectively, this smart delivery platform serves as a promising carrier to improve COVID-19 vaccination efficacy through its dual capabilities of vaccine delivery and in situ data storage, thus exhibiting great potential for helping to contain the COVID-19 pandemic or a resurgence.

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“…With an increase in the content of n-HAp, the fiber diameter decreased from 1847 ± 1039 nm to 845 ± 248 nm, and the scaffold was shown to be non-cytotoxic but antimicrobial using a rat tibial defect model [ 81 ]. The PCL/n-HAp (20%) groups prepared by RJS were implanted in a severe defect area of the tibia of rats for 60 days, the initial formation of the Havers system can be observed and the biological performance of the new bone can be improved [ 82 ]. Table 1 summarizes the n-HAp composite scaffolds for bone regeneration.…”

Section: N-hap Composite Scaffolds For Bone Repairmentioning

confidence: 99%

Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

Zhang

Liu

et al. 2023

IJMS

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Nano-hydroxyapatite (n-HAp) is similar to human bone mineral in structure and biochemistry and is, therefore, widely used as bone biomaterial and a drug carrier. Further, n-HAp composite scaffolds have a great potential role in bone regeneration. Loading bioactive factors and drugs onto n-HAp composites has emerged as a promising strategy for bone defect repair in bone tissue engineering. With local delivery of bioactive agents and drugs, biological materials may be provided with the biological activity they lack to improve bone regeneration. This review summarizes classification of n-HAp composites, application of n-HAp composite scaffolds loaded with bioactive factors and drugs in bone tissue engineering and the drug loading methods of n-HAp composite scaffolds, and the research direction of n-HAp composite scaffolds in the future is prospected.

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Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone

Cited by 11 publications

References 44 publications

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage

Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

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