Rotavirus-associated infantile diarrhea in Uberaba, Minas Gerais, on the wake of the Brazilian vaccination program

Distribution of rotavirus genotypes after vaccine introduction in the Triângulo Mineiro region of Brazil: 4-Year follow-up study

“…A trend in rotavirus disease reduction occurred in both cities (71.8% and 83.4% in Uberaba; 95.3% in Uberlândia) up to 2009, but it reversed in 2010 with increased rotavirus cases in Uberlândia. Short pattern G2P [4] strains were detected in all but three (96%) cases of mixed/P[NT] infections with long electropherotypes. Conclusions: This 4-year follow-up study showed a reduction in rotavirus-related diarrhea and even skipped a rotavirus season, which is consistent with vaccine mediated protection.…”

“…Conclusions: This 4-year follow-up study showed a reduction in rotavirus-related diarrhea and even skipped a rotavirus season, which is consistent with vaccine mediated protection. The 2007-2010 rotavirus epidemic curve reflected the natural cyclic fluctuation of the single G2P [4] genotype, with sharp reduction of cases in 2008 leading to lack of a rotavirus 2009 season (both cases and hospitalizations) followed by its come back in 2010. Diarrhea cases related to either vaccine serotype/genotype (G1 or P [8]) were not detected.…”

Group A rotavirus genotypes and the ongoing Brazilian experience: a review

“…The first period included 653 RV-A-positive samples that were collected from 1982-1995; these cases were reported in 15 papers in our literature review (Linhares et al 1988, Stewien et al 1994, Gusmão et al 1995, Leite et al 1996, Mascarenhas et al 1998, Cardoso et al 2000, 2001, Carmona et al 2004. The second period included 1,839 RV-A-positive samples that were collected from 1996-2005; these cases were reported in 19 articles in our literature review (Santos et al 1998, 2005b, Araújo et al 2002, Rosa-e-Silva et al 2002, Souza et al 2003, Luz et al 2005, Carmona et al 2006, Carvalho-Costa et al 2006, 2009, Pietruchinski et al 2006, Andreasi et al 2007, Gouvea et al 2007, Montenegro et al 2007, Martini et al 2008, Domingues et al 2008, Ribeiro et al 2008. Altogether, during the pre-vaccination era, 2,492 RV-A-positive faecal samples were typed, either by use of monoclonal antibody or PCR assays.…”

“…Only one paper in our review describes genotyping of RV-A-positive samples collected from 1994-1996 (i.e., during both defined periods), without specifying the results by year; therefore, this article has been reviewed separately (Macedo et al 2007). Finally, seven papers report 199 RV-A-positive samples that were collected after introduction of universal RV-A vaccination (2006RV-A vaccination ( -2007 (Araújo et al 2007a, Gouvea et al 2007, Gurgel et al 2007, Domingues et al 2008, Ribeiro et al 2008, CarvalhoCosta et al 2009). From these, five papers included samples collected before 2006, which were categorized as belonging to the pre-vaccination era.…”

Analysis of bovine rotavirus strains circulating in diarrheic dairy calves in Uberaba, Minas Gerais, Brazil, during 2008-2009

“…All positive samples were genotyped as G6P [5]; the predominance of this combination has been described in calves in Brazil (Alfieri et al, 2004) and other countries such as Australia and France (Swiatek et al, 2010;Kaplon et al, 2013). Differently from other genotypes of animal origin like G8, G5, G10 and G3, the G6 genotype has not yet been reported infecting humans in studies conducted in the Triângulo Mineiro region (Domingues et al, 2008;Dulgheroff et al, 2012). However, bovines may serve as reservoirs of the G6 genotype making its transmission to humans possible, so a continuous surveillance is still required.…”