Rötelsituation in Deutschland

Tischer, Annedore; Gerike, E

doi:10.1007/s001030070012

Cited by 5 publications

(7 citation statements)

References 29 publications

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“…Of women at the child-bearing age in the Eastern part of Germany 10% were found to be susceptible to rubella in 1990 [25] and this has probably reduced to 0.8±3% up to 1998 [30]. The relatively low rate (38%) of pregnant women with a history of rubella vaccination re¯ects the fact that in the former GDR, rubella immunization was only oered to seronegative young girls with occupational risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

Sauerbrei

Groh

Bischoff

et al. 2001

Med Microbiol Immunol

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Maternal and cord blood samples of 290 pregnant women in the eastern part of Germany with a mean age of 28 years (16-41 years) were analyzed for antibodies to vaccine-preventable diseases. Both mothers and infants had detectable levels of antibodies to mumps in 96% and to tetanus in 93% of cases. Detectable levels to poliomyelitis, diphtheria, measles and rubella varied from 55% to 91%. Cord blood samples had a significantly higher prevalence of antibodies to pertussis (61%) and diphtheria (81%) in comparison to maternal samples (pertussis 37%, diphtheria 70%) as well as significantly enhanced antibody concentrations to diphtheria. In conclusion, the prevalence of antibodies to pertussis (61%), diphtheria (81 %), poliomyelitis (55-59%) and measles (85%) is suggested to be insufficient in newborn infants to protect them against these infectious diseases.

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Section: Discussionmentioning

confidence: 99%

“…The primary objective of rubella immunization is the prevention of the congenital rubella syndrome (CRS). In Germany, at least 50 live born infants with CRS per year have to be expected [30]. The goal of the WHO to eradicate mumps, measles and congenital rubella in Europe by the year 2000 has not been achieved in Germany.…”

Section: Discussionmentioning

confidence: 99%

Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

Sauerbrei

Groh

Bischoff

et al. 2001

Med Microbiol Immunol

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“…In den letzten 30 Jahren hat sich hinsichtlich der Immunitätslage kaum etwas geändert, ausgenommen dass ein Teil der Wildvirusimmunität durch die der Impfvirusinfektion ersetzt wurde (2,14). Wie auch aus anderen Untersuchungen bekannt (2,14), finden sich die höchsten Immunitätsdefizite im Kindesalter.…”

Section: Diskussionunclassified

Untersuchungen zur Immunitätslage der impfpräventablen Kinderkrankheiten Röteln, Masern, Mumps und Windpocken

Buxbaum

Allwinn²

2004

Dtsch med Wochenschr

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“…anamnestische Daten über durchgemachte Infektionen unzuverlässig sind. [16], was der in den eigenen Untersuchungen gefundenen Immunitätslücke entspricht.Der Anteil seronegativer Frauen liegt damit deutlich über der Rate, die zwischen 1995 und 1998 in Seroprävalenzstudien ermittelt wurde [17]. Das Risiko des CRS betrug in der DDR 2-4 pro 1.000 lebendgeborenen Kindern [16].…”

Section: Immunität Gegen Mumpsunclassified

“…Das Risiko des CRS betrug in der DDR 2-4 pro 1.000 lebendgeborenen Kindern [16]. In Gesamtdeutschland muss heute noch mit einer jährlichen Inzidenz von mindestens 6 pro 100.000 Lebendgeburten gerechnet werden [17]. Eine genaue Zahl ist erst mit der Umsetzung der für das CRS eingeführten Meldepflicht im Rahmen des seit 2001 gültigen Infektionsschutzgesetzes zu erwarten.…”

Section: Immunität Gegen Mumpsunclassified

Antik�rper gegen impfpr�ventable Erkrankungen bei Schwangeren und deren Neugeborenen

Sauerbrei

Prager

Bischoff³

et al. 2004

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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In the eastern part of Germany, the age of primigravid women has clearly increased since 1990. This may change the protection provided by antibodies in pregnant women as well as their newborns. The objective of the present study was to assess antibodies against vaccine-preventable viral infectious diseases in pregnant women and their offspring to draw conclusions about their protection. Maternal and cord blood samples of 290 women from the eastern part of Germany with a mean age of 28 years were analyzed for antibodies against measles, mumps, rubella, poliomyelitis, and varicella. The study showed that the pregnant women had detectable levels of antibodies against measles virus in 79%, against mumps virus in 96%, against rubella virus in 87%, against polioviruses types 1-3 in 62-64%, and against varicella-zoster virus (VZV) in 97% of the cases. The seroprevalence of the antibodies in the newborns were not significantly different from those of their mothers. When antibody titers of mothers and newborns were compared, significantly higher titers to VZV could be detected in the cord blood sera of newborns. It is suggested that the prevalence of antibodies against measles and poliomyelitis is insufficient to protect the newborns efficiently. An immunity gap of 13% against rubella in mothers results in a potential risk for a congenital rubella syndrome in newborns. Despite the high seroprevalence of rubella and chickenpox, there is considerable potential for infections during pregnancy and neonatal period.

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Rötelsituation in Deutschland

Cited by 5 publications

References 29 publications

Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany

Untersuchungen zur Immunitätslage der impfpräventablen Kinderkrankheiten Röteln, Masern, Mumps und Windpocken

Antik�rper gegen impfpr�ventable Erkrankungen bei Schwangeren und deren Neugeborenen

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