Generalized chaos systems have more complex dynamic behavior than conventional chaos systems. If a generalized response system can be synchronized with a conventional drive system, the flexible control parameters and unpredictable synchronization state will increase significantly. The study first constructs a four-dimensional nonlinear dynamic equation with quadratic variables as a drive system. The numerical simulation and analyses of the Lyapunov exponent show that it is also a chaotic system. Based on the generalized chaos synchronization (GCS) theory, a four-dimensional diffeomorphism function is designed, and the corresponding GCS response system is generated. Simultaneously, the structural and synchronous circuits of information interaction and control are constructed with Multisim TM software, with the circuit simulation resulting in a good agreement with the numerical calculations. In order to verify the practical effect of generalized synchronization, an RGB digital image secure communication scheme is proposed. We confuse a 24-bit true color image with the designed GCS system, extend the original image to 48-bits, analyze the scheme security from keyspace, key sensitivity and non-symmetric identity authentication, classical types of attacks, and statistical average from the histogram, image correlation. The research results show that this GCS system is simple and feasible, and the encryption algorithm is closely related to the confidential information, which can resist the differential attack. The scheme is suitable to be applied in network images or other multimedia safe communications.