Routine antibiotic use in preterm neonates: a randomised controlled trial

Tagare, Amit; Vaidya, Umesh; Pandit, Anand

doi:10.1016/j.jhin.2009.09.010

Cited by 26 publications

(27 citation statements)

References 19 publications

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“…Early AB regimen, however, remained a borderline significant predictor of mortality in multivariate analysis adjusted for the random clustering effect (treatment period and study center), as well as for other known risk factors of mortality in ELBW neonates, 31 suggesting a true difference. The potential of empiric AB therapy to prevent culture positivity in preterm neonates without altering the incidence of clinical sepsis has been demonstrated in a recent randomized controlled trial by Tagare et al 36 The effect may be explained by the different antibacterial spectrum of the studied AB regimens. PEN is an AB with a narrow spectrum of activity, limited mostly to Gram-positive organisms; in the context of EOS mainly to GBS.…”

Section: Discussionmentioning

confidence: 99%

Ampicillin versus penicillin in the empiric therapy of extremely low‐birthweight neonates at risk of early onset sepsis

Metsvaht

Ilmoja

Parm

et al. 2011

Pediatrics International

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Section: Discussionmentioning

confidence: 99%

Ampicillin versus penicillin in the empiric therapy of extremely low‐birthweight neonates at risk of early onset sepsis

Metsvaht

Ilmoja

Parm

et al. 2011

Pediatrics International

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“…A recent retrospective cohort study involving 5693 premature babies found that the prolonged use (greater than 5 days) of antibiotic therapy was associated with and increased the risk of NEC [106]. The use of antibiotics for 5 days or less in premature infants was thoroughly assessed in a large RCT and no increase in the incidence of NEC was found between the control group and the study group [107]. …”

Section: Antibioticsmentioning

confidence: 99%

What Really Causes Necrotising Enterocolitis?

Fox

Godavitarne

2012

ISRN Gastroenterology

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Background. One of the most serious gastrointestinal disorders occurring in neonates is necrotising enterocolitis (NEC). It is recognised as the most common intra-abdominal emergency and is the leading cause of short bowel syndrome. With extremely high mortality and morbidity, this enigmatic disease remains a challenge for neonatologists around the world as its definite aetiology has yet to be determined. As current medical knowledge stands, there is no single well-defined cause of NEC. Instead, there are nearly 20 risk factors that are proposed to increase the likelihood of developing NEC. Aims and Objectives. The aim of this project was to conduct a comprehensive literature review around the 20 or so well-documented and less well-documented risk factors for necrotising enterocolitis. Materials and Methods. Searches of the Medline, Embase, and Science direct databases were conducted using the words “necrotising enterocolitis + the risk factor in question” for example, “necrotising enterocolitis + dehydration.” Search results were ordered by relevance with bias given to more recent publications. Conclusion. This literature review has demonstrated the complexity of necrotising enterocolitis and emphasised the likely multifactorial aetiology. Further research is needed to investigate the extent to which each risk factor is implicated in necrotising enterocolitis.

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“…The effect of prior antibiotic use on blood cultures was reported by Tagare et al Bacterial isolation was 55% in neonates with no exposure to antibiotics compared with 4.5% in neonates who had already received antibiotics. 16 This was almost a 10 times reduction in bacterial isolation. This may explain the varied rates of blood culture isolation.…”

Section: Discussionmentioning

confidence: 98%

Pattern and Antimicrobial Susceptibility of Neonatal Sepsis at a Tertiary Care Center in Western India

Dhanawade

Tagare

Gadre

et al. 2016

J Pediatr Infect Dis

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Changing trends in neonatal sepsis is documented worldwide. We reviewed blood culture reports over a 3-year period. Out of 1,020 blood cultures sent from 620 neonates with suspected sepsis, 127 (12.4%) were positive. Gram-negative and gram-positive pathogens constituted 68.2% and 31.78%, respectively. Klebsiella was the most common organism (37/127) followed by Staphylococcus aureus (25/127), Acinetobacter (18/127), Escherichia coli (18/127), and Enterococci spp. (12/127). Gram-negative organisms were highly resistant to ampicillin (84.8%), gentamicin (81.3%), and cefotaxime (71.3%). Carbapenem resistance was observed in 26.6% of gram-negative pathogens. Vancomycin resistance among enterococci was 40%, and 12% of S. aureus strains were methicillin resistant. Mortality rate was 29.13% and was highest (44.44%) in Acinetobacter sepsis.

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Routine antibiotic use in preterm neonates: a randomised controlled trial

Cited by 26 publications

References 19 publications

Ampicillin versus penicillin in the empiric therapy of extremely low‐birthweight neonates at risk of early onset sepsis

Ampicillin versus penicillin in the empiric therapy of extremely low‐birthweight neonates at risk of early onset sepsis

What Really Causes Necrotising Enterocolitis?

Pattern and Antimicrobial Susceptibility of Neonatal Sepsis at a Tertiary Care Center in Western India

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