Routine duodenal biopsies to exclude celiac disease?

Routine Duodenal Biopsies in the Absence of Endoscopic Markers of Celiac Disease Are Not Useful: An Observational Study

“…However, subsequent studies reported lower endoscopic marker sensitivity, even as low as 50%. Much of this research looked at the utility of endoscopic markers in patients with dyspepsia [2,3,5,7]. Bardella et al found endoscopic markers to be only 50% positive in a prospective study of 517 patients.…”

“…For example, scalloping or loss of duodenal folds, mosaic pattern, and nodularity can serve as endoscopic markers of the disease [6,7,9,10]. These observations may indicate a need for duodenal biopsies in patients that present both typical and atypical presentations of CD.…”

“…Although serological tests are reliable, endoscopic biopsies are essential in diagnosing the disease because they allow for direct observation of histologic abnormalities compatible with CD [1][2][3][4][5][6]. Therefore some centers encourage routine endoscopic biopsies in all patients with upper gastrointestinal symptomatology [7,8]. One advantage of early diagnosis and treatment can be reduced medical costs.…”

Celiac Disease in Bangladesh – Two Case Reports

“…Growth failure may be due to malabsorption, chronic diarrhoea and increased catabolism. 10,2 Wide spectrum of liver injury occurs in celiac disease. The 2nd case presented with raised ALT with histological features of chronic hepatitis with mild fatty changes.…”

Anti-GM1 ganglioside antibodies, neuron specific enolase and interleukin 10 concentrations as potential markers of autonomic nervous system impairment in celiac disease - preliminary findings

“…The 3a-c level is the most typical of CD. 31,32 Analysis of autonomic nervous system and gastric myoelectrical activity ANS activity was recorded as the assessment of HRV at rest (Task Force Monitor 3040i, CNSystems, Graz, Austria). The myoelectric activity of the stomach (EGG) the study and gave their informed consent to participate in the study.…”