Routine Laboratory Parameters as a Tool for Predicting Death in Patients With COVID-19

Abstract

Background: The complexity of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) makes the clinical course of the disease develop rapidly, causing severe and deadly complications. Identifying effective laboratory biomarkers able to predicting patients based on their risk. This study aimed to look for those serobiomarkers in hospitalized patients with Coronavirus Disease 2019 (COVID‐19). Materials and Methods: In this retrospective observational study, 114 patients with COVID-19, admitted to Valian hospital in Aligudarz, City, Iran from October to December 2020 were examined. The disease outcome was followed along with the hospital course of every patient at the time of analysis. Laboratory investigations of all patients were monitored at the time of admission. A comparative analysis was done between the survivors (n=73) and non-survivors (n=41). Statistical analysis was conducted using SPSS. Results: Of the 114 patients, 40.4% (n=41) were non-survivor, and there were significant differences in Hemoglobin (Hb), Hematocrit (Hct), Platelet (PLT), Alkaline Phosphatase (ALP), Total Bilirubin, Fasting Blood Suger (FBS), Total Iron-Binding Capacity (TIBC), Lactate Dehydrogenase (LDH), Blood Urea Nitrogen (BUN), Creatinine (Cr), Albumin (ALB), and C-Reactive Protein (CRP) between survivors and non-survivors. Conclusion: The laboratory parameters have fundamental roles in poor prognosis and mortality prediction rated among patients with COVID-19 in the first admission. Thus, it is highly recommended to collaborate among hematologists, health managers, and clinical especialists.

In Silico Prediction of Hub Genes Involved in Diabetic Kidney and COVID-19 Related Disease by Differential Gene Expression and Interactome Analysis

“…Notably, a higher mortality rate of COVID-19 has been reported in end-stage renal disease and kidney transplant patient recipients. Recent literature describes SARS-CoV-2 infections in diabetes and DKD; for detailed review, see [ 7 , 9 ]. These medical literature points out that patients with both pathologies (DKD and COVID-19) develop multiple pathophysiological mechanisms between the lung and kidney organs.…”

Discovering hub genes involved in the pathophysiological impact of COVID-19 on diabetes kidney disease by differential gene expression and interactome analysis

“…for detailed review [23,25]. This medical literature points out that patients with both pathologies (DKD and COVID- 19) develop multiple pathophysiological mechanisms between the lung and kidney organs.…”

“…Remarkably, since the beginning of the COVID-19 pandemic, it has been observed that those comorbidities, including the development of diabetes chronic kidney disruptions, are associated with severe symptoms in patients with SARs-CoV-2 variants [21-24]. There are recent literature describing SARS-CoV-2 infections in diabetes and DKD; for detailed review [23,25]. This medical literature points out that patients with both pathologies (DKD and COVID-19) develop multiple pathophysiological mechanisms between the lung and kidney organs.…”