Routine Methods in Toxicology and Therapeutic Drug Monitoring by High Performance Liquid Chromatography

Development and Validation of a Liquid Chromatographic Method for the Determination of Furosemide, a Diuretic, in Bovine Milk

“…The LC analysis is generally preceded by sample cleanup with the exception of direct injection into internal surface reversed phase column (Pinkerton et al, 1986). The sample cleanup involves deproteination with acetonitrile (Sidhu and Charles, 1993;Radek and Heller, 1989;Saugy et al, 1991), methanol (Sood et al, 1987), or acid followed by ethyl acetate extraction (Ray et al, 1984;Reeuwijik et al, 1992). Solid phase extraction alone (Russel et al, 1989;Radek and Heller, 1989) and solid phase extraction with on-line elution via an advanced automated sample processor (AASP) have also been used for sample cleanup of plasma samples (Forthing et al, 1992).…”

Rp-HPLC Method for the Simultaneous Estimation of Lisinopril and Diuretics in Bulk, Dosage Forms and Human Serum

“…Literature study also revealed that various spectrometric and RP-HPLC methods were reported for the individual determination of LIS [10][11][12][13][14][15][16][17][18], HCT [19][20] and FUR [21][22][23].…”