Routine plasma colloid osmotic pressure measurements

Weil, Max Harry; Morissette, Martin; Michaels, Sybil; Bisera, Joe; Boycks, Edward; Shubin, Herbert; Jacobson, Edwin

doi:10.1097/00003246-197409000-00001

Cited by 79 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, the average COP ± SD in five healthy pre-term neonates was reported to be 15.4 ± 1.3 mmHg [16], compared with an average of 25 mmHg in adults [19,20]. The COP in 40 sick pre-term neonates was also significantly lower (12.4 ± 1.6 mmHg) compared with healthy pre-term neonates [16].…”

Section: Discussionmentioning

confidence: 99%

Plasma colloid osmotic pressure in healthy infants

2001

View full text Add to dashboard Cite

IntroductionPlasma COP is generated by the plasma proteins, particularly albumin, and is known to vary during various neonatal diseases [1][2][3][4]. Lower plasma COP favors a fluid shift from intravascular space into interstitial space, with subsequent formation of peripheral and pulmonary edema [3][4][5][6][7][8]. To stabilize the intravascular volume and prevent or reverse the events leading to peripheral and pulmonary edema, albumin or other colloid solutions are frequently administered, to maintain the COP in the 'normal' range [7][8][9][10][11][12]. Albumin administration for various conditions, however, is controversial [13][14][15]. Plasma COP in healthy neonates, sick neonates, and prematurely born infants are reported to be much lower than in adults [16][17][18]. The normal range of COP for healthy adults is reported to be between 22 and 28 mmHg, with a mean of 25 mmHg [19,20]. There is, however, no information in the literature on normal COP range beyond the early neonatal age. The adult COP values in our intensive care unit are also considered to be ANOVA = analysis of variance; COP = colloid osmotic pressure; SD = standard deviation. AbstractBackground The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults. Methods Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses. Results Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r 2 = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r 2 = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 ± 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1-3 months [n = 11], 5-8 months [n = 13] and 9-11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 ± 2.4 mmHg in 19 male infants compared with 25.2 ± 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg. Conclusions The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in ...

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma colloid osmotic pressure in healthy infants

2001

View full text Add to dashboard Cite

show abstract

“…colloid osmotic pressure; extracorporeal circulation; hemodialysis; plasma volume Because most of the fluid removed by hemodialysis (HD) or extracorporeal ultrafiltration method (ECUM) comes from the interstitial space of the body (Kimura et al 1984), we have to pay attention to the exchange of body fluid between the interstitial space and vessels. The exchange is affected to a considerable degree by colloid osmotic pressure (COP), produced by the plasma proteins such as albumin, globulin, fibrinogen and other macromolecules (Weil et al 1974). COP is one of the important components of Starling's hypothesis that prescribes body fluid balance between interstitial space and vessels (Starling 1896).…”

mentioning

confidence: 99%

Development of an Apparatus to Measure Plasma Colloid Osmotic Pressure Mounted on the Extracorporeal Hemodialysis Circuit.

Abe

Ooishi

Sato

et al. 1995

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

“…The fluid volume in the extracorporeal circuit was about triple the blood volume of the infants. Therefore, COP levels during CPB using a crystalloid hemodilution could be significantly lower than normal values (21.6+3.6 mmHg; Weil et al 1974). Colloid hemodilution in Group B, on the other hand, resulted in COP levels within normal range during CPB and in significantly less fluid accumulation in the body.…”

Section: Discussionmentioning

confidence: 88%