Routine use of EmbryoGlue® as embryo transfer medium does not improve the ART outcomes

Safari, Somayyeh; Razi, Mohammad Hossein; Safari, Samira; Razi, Y

doi:10.1007/s00404-014-3416-0

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…Reports have suggested that adding HA to the ET medium can increase the IR and PR . Furthermore, the current findings corroborate the results reported by other studies that concluded HA may have beneficial effects in patients with RIF . Taken together, the aforementioned studies suggest the addition of HA to the transfer medium in patients with RIF significantly increases the IR and PR, while not affecting ectopic pregnancy and abortion rates.…”

Section: Discussionsupporting

confidence: 90%

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Effect of hyaluronic acid–enriched transfer medium on frozen–thawed embryo transfer outcomes

Zhang

2018

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 90%

“…Several studies have indicated that HA‐enriched medium can improve the IR and clinical PR . In contrast, other studies have reported no beneficial effects of HA …”

Section: Introductionmentioning

confidence: 99%

Effect of hyaluronic acid–enriched transfer medium on frozen–thawed embryo transfer outcomes

Zhang

2018

J of Obstet and Gynaecol

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“…6 Several authors state that HA-enriched media have not shown significant results in their study 2,19 and concluded that future research should show whether EG is the highest quality option for all patients or only for those patients in whom the quality of the embryo is poor, for patients in whom implantation has failed and older patients. 20 Nishihara et al 21 state that pregnancies, implantation, and abortion rates where media with different concentrations of HA was used during ET gives similar results.…”

Section: Discussionmentioning

confidence: 96%

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Pavlović-Vasić¹,

Sibinčić²,

Milaković³

et al. 2021

Scripta Medica

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Introduction: Thanks to ever-growing advances in medical science, couples who are in the in vitro fertilisation (IVF) now have more options than ever to encase their chances at a successful pregnancy. One of the options is the use of EmbryoGlue (EG), that creates a bridge between the embryo and the uterus and provides protection to the embryo itself during the transfer process. Aim of this study was to determine whether EG medium is of greater importance for embryo implantation than conventional medium in assisted reproductive technology and compare the rate of embryo implantation with EG and conventional medium in relation to the quality of the embryo, the age of the patients and tobacco smoking. Methods: The retrospective study included 50 patients who used EG medium in embryo transfer (ET) and 50 patients in the control group using conventional medium. All patients underwent ET after stimulation of the cycle according to a short protocol. ETs were done on Day 2, 3, or 5 in the blastocyst stage. Age and smoking status were recorded. Results: Out of a total of 100 patients, 42 patients had successful implantation and positive b-hCG 15 days after ET. In a control group 38 % had positive b-hCG and in the group of patients who used EG 46 %. A higher rate of embryo implantation success was observed on the second day of transfer in the group of patients using EG. In the EG group a significant increase in the embryo implantation rate was observed in patients older than 35. In tobacco smokers the implantation rate was higher if they used EG during ET. Conclusion: EG medium had a positive effect on the second day of ET, patients above the age of 35 and patients who were tobacco smokers.

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“…17 A retrospective study conducted by Safari et al showed no significant advantage to using EmbryoGlue in embryo transfer media for good prognosis patients (live birth rate: p ¼ 1.0, n ¼ 229), and suggested that it may have more success in poor prognosis patients (RIF, poor-quality embryos, and advanced age. 18 EmbryoGlue is indicated for use in patients with RIF and advanced age (>35 years), with studies showing improved implantation and clinical pregnancy rates (odds ratio [OR]: 1.28; 1.43, 95% confidence interval [CI]: 1.03-1.59, n ¼ 1,282). 19 HETM is purported to improve implantation and pregnancy rates in patients undergoing frozen embryo transfer (FET), with the effect dependent on the number of previous FETs.…”

Section: Recent Evidencementioning

confidence: 99%

Embryo Glue: The Use of Hyaluronan in Embryo Transfer Media

Atkinson

Woodland

2021

Semin Reprod Med

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EmbryoGlue is available to patients at many in vitro fertilization clinics, usually at an additional cost. The efficacy of hyaluronan-enriched transfer medium (HETM) is supported by moderate quality evidence that indicates a significant improvement in clinical outcomes such as live birth rates for patients, including poorer prognosis women (i.e., maternal age factor [>35 years] and recurrent implantation failure). An increased multiple pregnancy rate has been reported with the use of HETM; therefore, a single embryo transfer policy should be considered in conjunction with the use of EmbryoGlue. There is no evidence to suggest that HETM has any detrimental impact, and therefore the use of HETM in clinics may be justified for a specific demographic of patients. Further robust evidence, in the form of meta-analyses or large-scale randomized controlled trials, is needed to build a sufficient consensus regarding the benefit of hyaluronan supplementation in embryo transfer media.

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Routine use of EmbryoGlue® as embryo transfer medium does not improve the ART outcomes

Abstract: Routine use of EmbryoGlue(®)as a HA enriched ET medium for cleavage stage embryos does not have advantage to the conventional one for infertile patients undergoing ART.

Cited by 10 publications

References 15 publications

Effect of hyaluronic acid–enriched transfer medium on frozen–thawed embryo transfer outcomes

Effect of hyaluronic acid–enriched transfer medium on frozen–thawed embryo transfer outcomes

Influence of EmbryoGlue® transfer medium on implantation of human embryos

Embryo Glue: The Use of Hyaluronan in Embryo Transfer Media

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