Royal jelly regulates the caspase, Bax and COX-2, TNF-α protein pathways in the fluoride exposed lung damage in rats

Aslan, Abdullah Nabi; Gök, Özlem; Beyaz, Seda; Can, Muhammed İsmail; Parlak, Gozde; Gündoğdu, Ramazan; Ozercan, İbrahim Hanifi; Başpınar, Serpil

doi:10.1016/j.tice.2022.101754

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…COX-2 was expressed as a few granules in normal livers, mainly in the sinusoidal lining. Excessive COX-2 expression is accompanied by inflammation and tissue injury [ 113 ]. This is compatible with our result of COX-2 in the GA3-treated group as it was expressed in the inflamed hepatocytes, sinusoidal lining including endothelial and Kupffer cells mainly surrounding collagen proliferation and inflammatory cell infiltration.…”

Section: Discussionmentioning

confidence: 99%

“…This agreed with that mentioned by Denda [ 114 ] who stated that the Kupffer cells were the main hepatic prostanoids producers. RJ reduces tissue damage through the reduction of TNF-α and COX-2 expression [ 113 ]. CV administration inhibits the COX-2 expression due to their inhibitory activity that blocks the inflammatory mediator’s formation by COX-2 inhibitors as discussed by Cheng et al [ 115 ].…”

Section: Discussionmentioning

confidence: 99%

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Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Khadrawy

Mohamed

Hassan

et al. 2023

Foods

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Gibberellic acid (GA3) is a well-known plant growth regulator used in several countries, but its widespread use has negative effects on both animal and human health. The current study assesses the protective effect of royal jelly (RJ) and Chlorella vulgaris (CV) on the genotoxicity and hepatic injury induced by GA3 in rats. Daily oral administration of 55 mg/kg GA3 to rats for 6 constitutive weeks induced biochemical and histopathological changes in the liver via oxidative stress and inflammation. Co-administration of 300 mg/kg RJ or 500 mg/kg CV with GA3 considerably ameliorated the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), γGT (gamma-glutamyl transferase), total bilirubin, and albumin. Lowered malondialdehyde, tumor necrosis factor α (TNF-α), and nuclear factor κB (NF-κB) levels along with elevated SOD (superoxide dismutase), CAT (catalase), and GPx (glutathione peroxidase) enzyme activities indicated the antioxidant and anti-inflammatory properties of both RJ and CV. Also, they improved the histological structure and reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions along with up-regulating peroxisome proliferator activated receptor α (PPARα) and down-regulating activator protein 1 (AP-1) gene expression. Additionally, chromosomal abnormalities and mitotic index were nearly normalized after treatment with RJ and CV. In conclusion, RJ and CV can protect against GA3-induced genotoxicity and liver toxicity by diminishing oxidative stress and inflammation, and modulating the PPARα/AP-1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Khadrawy

Mohamed

Hassan

et al. 2023

Foods

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“…Recent studies have shown that supplementing zebrafish diets with royal jelly can improve growth performance and positively affect the mRNA expression levels of growth hormones (GH-1 and IGF-1) and immune function-related factor TGF-β (Vural et al, 2021). Moreover, it has been found that there is a relationship between nutrition and health of humans, fish, rats, and livestock, and it depends on the optimal feed composition and its utilization (Abdelnour et al, 2020;Aksakal et al, 2021;Aslan et al, 2022). The current investigation is a followup of two previous studies by Aksakal et al (2021) and Vural et al (2021), which evaluated the relative effectiveness of feeding zebrafish diets with varying RJ supplementation on whole-body FA composition.…”

Section: Discussionmentioning

confidence: 99%

Is royal jelly a sustainable alternative lipid source in aquaculture? Influence of dietary royal jelly levels on fatty acid composition in zebrafish

Vural¹,

Tunç²,

Kamaszewski³

et al. 2023

J. Anim. Feed Sci.

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“…This may be due to low-grade systemic inflammation through the cholinergic pathway ( 131 ). Besides, NaF significantly increases the mRNA and protein levels of MAPK signaling pathways and significantly inhibits the production of pro-inflammatory mediators such as IL-1β, IL-6, IL-8, monocyte chemotactic protein 1, and cyclooxygenase-2 and anti-inflammatory mediators, including IL-4 and TGF-β, thus resulting in the body’s immune dysfunction and inflammatory response ( 132 – 134 ).…”

Section: Effects Of Fluoride On Immun-active Substancementioning

confidence: 99%

Progress in research on the role of fluoride in immune damage

Zhu,

Wei

2024

Front. Immunol.

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Excessive fluoride intake from residential environments may affect multiple tissues and organs; however, the specific pathogenic mechanisms are unclear. Researchers have recently focused on the damaging effects of fluoride on the immune system. Damage to immune function seriously affects the quality of life of fluoride-exposed populations and increases the incidence of infections and malignant tumors. Probing the mechanism of damage to immune function caused by fluoride helps identify effective drugs and methods to prevent and treat fluorosis and improve people’s living standards in fluorosis-affected areas. Here, the recent literature on the effects of fluoride on the immune system is reviewed, and research on fluoride damage to the immune system is summarized in terms of three perspectives: immune organs, immune cells, and immune-active substances. We reviewed that excessive fluoride can damage immune organs, lead to immune cells dysfunction and interfere with the expression of immune-active substances. This review aimed to provide a potential direction for future fluorosis research from the perspective of fluoride-induced immune function impairment. In order to seek the key regulatory indicators of fluoride on immune homeostasis in the future.

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Royal jelly regulates the caspase, Bax and COX-2, TNF-α protein pathways in the fluoride exposed lung damage in rats

Cited by 8 publications

References 35 publications

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Is royal jelly a sustainable alternative lipid source in aquaculture? Influence of dietary royal jelly levels on fatty acid composition in zebrafish

Progress in research on the role of fluoride in immune damage

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