RP-HPLC determination of atorvastatin calcium and amlodipine besylate combination in tablets

Size Control of Atorvastatin Calcium Particles Based on Spherical Agglomeration

“…The flow rate was 0.8 mL min −1 and the UV detector wavelength was set at 244 nm. The column temperature was 35 °C 12.…”

Simultaneous determination of metoprolol succinate and amlodipine besylate in pharmaceutical dosage form by HPLC

“…USP 2006 describes an HPLC method for determination of MS as extended release tablets [3]. Few HPLC methods are reported in the literature for the simultaneous determination of some antihypertensive drugs from pharmaceutical dosage forms [4][5][6][7][8][9][10][11]. So far, to our present knowledge, no HPLC method is reported for the simultaneous determination of metoprolol succinate and amlodipine besylate in dosage forms.…”

Development and Validation of Stability-Indicating HPLC Methods for Quantitative Determination of Pravastatin, Fluvastatin, Atorvastatin, and Rosuvastatin in Pharmaceuticals

“…Although these methods are sensitive enough to permit their use in determination of PS, FV, ATC, and RC in urine, plasma, and serum, few methods are reported for assay of statins in pharmaceuticals. Among them, HPLC methods have been described using expensive reagents or buffers in the mobile phase, which make them Stability-Indicating HPLC Methods 1785 less attractive for routine analysis (Chaudhari, Manilal, and Bhagvatiprasad 2007;Mohammadi et al 2007;Onal and Sagirli 2006;Rajeswari et al 2006;Rajkondawar 2006;Rani and Reddy 2006;Shah et al 2006;Sonawane et al 2006;Stanisz and Lukasz 2006;Freddy and Chaudhari 2005;Kocijan et al 2005;Ertuerk et al 2003;Puratchikody et al 2003;United States Pharmacopeia 2008). Some spectrophotometric methods have been reported for the determination of statins by complexation with metal ions or complex reagents (Krishna and Sankar 2007;Uyar, Celebier, and Altinoz 2007;Krishna and Sankar 2006;Khan and Jain 2006;Salem et al 2006;Prabhakar, Shobha, and Appala 2005;Erk 2003;Rao et al 2003).…”