RP-HPLC–PDA Approach for Concurrent Analysis of Telmisartan and Azelnidipine in Bulk and Commercial Tablets

Godela, Ramreddy; Gummadi, Sowjanya; Pathak, Shilpi; Pola, Kranthi Kumar; Yagnambhatla, Rajendra

doi:10.1007/s42250-022-00483-5

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…AZEL is a third-generation and long-acting dihydropyridine calcium channel antagonist used for the treatment of hypertension [1]. So far, numerous methodologies have been developed for the estimation of AZEL based on different analytical techniques such as UV-visible spectrophotometry [3][4][5][6][7][8], high-performance liquid chromatography (HPLC)/reverse phase (RP)-HPLC [9][10][11][12][13], ultraperformance/pressure liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) [14], ultra-fast liquid chromatography (UFLC) [15], LC-ESI-MS/MS [16], HPLC-MS/MS [17], and high-performance thin layer chromatography (HPTLC) [18] for the estimation of AZEL alone, as well as in combination with other drugs in pharmaceutical dosage forms [19]. However, these methods have their limitations requiring more expensive instruments, a large quantity of samples, the use of costly organic solvents, complex mathematic dealing, and robust sample handling, and they are time consuming.…”

Section: Introductionmentioning

confidence: 99%

Selective detection of azelnidipine in pharmaceuticals via carbon dot mediated spectrofluorimetric method: A green approach

Lodha,

Gore,

Merchant

et al. 2024

Luminescence

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A spectrofluorimetric method using fluorescent carbon dots (CDs) was developed for the selective detection of azelnidipine (AZEL) pharmaceutical in the presence of other drugs. In this study, N‐doped CDs (N‐CDs) were synthesized through a single‐step hydrothermal process, using citric acid and urea as precursor materials. The prepared N‐CDs showed a highly intense blue fluorescence emission at 447 nm, with a photoluminescence quantum yield of ~21.15% and a fluorescence lifetime of 0.47 ns. The N‐CDs showed selective fluorescence quenching in the presence of all three antihypertensive drugs, which was used as a successful detection platform for the analysis of AZEL. The photophysical properties, UV–vis light absorbance, fluorescence emission, and lifetime measurements support the interaction between N‐CDs and AZEL, leading to fluorescence quenching of N‐CDs as a result of ground‐state complex formation followed by a static fluorescence quenching phenomenon. The detection platform showed linearity in the range 10–200 μg/ml (R2 = 0.9837). The developed method was effectively utilized for the quantitative analysis of AZEL in commercially available pharmaceutical tablets, yielding results that closely align with those obtained from the standard method (UV spectroscopy). With a score of 0.76 on the ‘Analytical GREEnness (AGREE)’ scale, the developed analytical method, incorporating 12 distinct green analytical chemistry components, stands out as an important technique for estimating AZEL.

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