rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

Patarca, Roberto; Freeman, Gordon J.; Schwartz, Joel L.; Singh, Rajesh; Kong, Qui-Tong; Murphy, Ellen; Anderson, Y.; Sheng, F. Y.; Singh, Pratima; Johnson, Kirk

doi:10.1073/pnas.85.8.2733

Cited by 131 publications

(56 citation statements)

References 39 publications

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“…The C terminus of Ro52 shares homologies with two other zinc finger-bearing proteins, mouse regulatory protein T lymphocyte-1 and human ret finger protein, as well as with butyrophilin, a glycoprotein expressed in mammary tissues (27,34). Therefore, our findings suggest that Ro52 might interact with genes in T cells and regulate the transcription of IL-2 as a transcriptional factor or regulator of other transcription factors.…”

Section: Discussionmentioning

confidence: 81%

SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production

Ishii

Ohnuma

Murakami

et al. 2003

The Journal of Immunology

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An autoantibody against SS-A/Ro52 (Ro52) is most frequently found in the sera of patients with Sjögren’s syndrome, systemic lupus erythematosus, and congenital heart block from anti-Ro52 Ab-positive mother. However, the physiological function of the autoantigen SS-A/Ro52 has not yet been elucidated. In this study, we describe the role of Ro52 protein in T cell activation. Overexpression of SS-A/Ro52 in Jurkat T cell resulted in enhanced IL-2 production following CD28 stimulation. Furthermore, transfection of anti-Ro52-specific small RNA duplexes partially blocked the expression of native and overexpressed Ro52 in Jurkat T cell, resulting in decreased IL-2 production via CD28 pathway in these cells. Finally, intracellular localization of Ro52 dramatically changed following CD28 stimulation. Our data reveal a novel function of Ro52 in CD28-mediated pathway, which eventually contributes to cytokine production and expression of the T cell biological programs.

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Section: Discussionmentioning

confidence: 81%

SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production

Ishii

Ohnuma

Murakami

et al. 2003

The Journal of Immunology

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“…In addition, a number of cellular transcriptional factors can repress virus often through the viral long terminal repeat (LTR). These factors include the c-myc promoter binding protein (MBP-1), the tumor suppressor p53, the transcriptional factor YY-1, the regulatory protein T lymphocyte-1, the transcriptional factor E2F1, and the NF-B (12)(13)(14)(15). All are, in part, regulated by HIV-1 and affect viral production.…”

Section: Ononuclear Phagocytes (Mpmentioning

confidence: 99%

Molecular Characterization of a Putative Antiretroviral Transcriptional Factor, OTK18

Carlson

Leisman

Limoges

et al. 2004

The Journal of Immunology

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Elucidation of the factors involved in host defense against human immunodeficiency viral infection remains pivotal if viral control may be achieved. Toward these ends, we investigated the function of a putative antiretroviral factor, OTK18, isolated by differential display of mRNA from HIV type 1-infected primary human monocyte-derived macrophages. Molecular and immunohistochemical analyses showed that the OTK18 nucleotide sequence contains 13 adjacent C2H2-type zinc finger motifs, a Krüppel-associated box, and is localized to both cytosol and nucleus. Mutational analyses revealed that both the Krüppel-associated box and zinc finger regions of OTK18 are responsible for the transcriptional suppressive activities of this gene. OTK18 was copiously expressed in macrophages following HIV type I infection and diminished progeny virion production. A mechanism for this antiretroviral activity was by suppression of HIV type 1 Tat-induced viral long terminal repeat promoter activity. Our findings suggest that one possible function of OTK18 is as a HIV type 1-inducible transcriptional suppresser.

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“…Percent identity refers to just the RING finger domain. Alignment of B-box motifs: Sources for RING fingers and BBox motifs used in this comparison are RAD18 (Jones et al 1988); RPT-1 (Patarca et al 1988); PSC, SU(Z)2 (Brunk et al 1991); SS-A/Ro (Chan et al 1991); XNF7 (Reddy et al 1991); RAD16 (Bang et al 1992); PML (Kastner et al 1992); PAF-1 (Shimozawa et al 1992); PwA33 (Bellini et al 1993); MEL-18 (Ishida et al 1993); PAR-2 (Levitan et al 1994); BRCA1 (Miki et al 1994); HT2A (Fridell et al 1995); T18 (Miki et al 1991;LeDoyerin et al 1995); RFP (Cao et al 1997); RING1 (Satijn et al 1997); BMI-1 (Hemenway et al 1998); and XL43, XL75 (Perrin and Lacroix 1998).…”

Section: Tam-1 and Context-dependent Gene Silencingmentioning

confidence: 99%

The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans

Hsieh¹,

Liu²,

Kostas³

et al. 1999

Genes & Development

103

105

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Context-dependent gene silencing is used by many organisms to stably modulate gene activity for large chromosomal regions. We have used tandem array transgenes as a model substrate in a screen for Caenorhabditis elegans mutants that affect context-dependent gene silencing in somatic tissues. This screen yielded multiple alleles of a previously uncharacterized gene, designated tam-1 (for tandem-array-modifier). Loss-of-function mutations in tam-1 led to a dramatic reduction in the activity of numerous highly repeated transgenes. These effects were apparently context dependent, as nonrepetitive transgenes retained activity in a tam-1 mutant background. In addition to the dramatic alterations in transgene activity, tam-1 mutants showed modest alterations in expression of a subset of endogenous cellular genes. These effects include genetic interactions that place tam-1 into a group called the class B synMuv genes (for a Synthetic Multivulva phenotype); this family plays a negative role in the regulation of RAS pathway activity in C. elegans. Loss-of-function mutants in other members of the class-B synMuv family, including lin-35, which encodes a protein similar to the tumor suppressor Rb, exhibit a hypersilencing in somatic transgenes similar to that of tam-1 mutants. Molecular analysis reveals that tam-1 encodes a broadly expressed nuclear protein with RING finger and B-box motifs.

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rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

Cited by 131 publications

References 39 publications

SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production

SS-A/Ro52, an Autoantigen Involved in CD28-Mediated IL-2 Production

Molecular Characterization of a Putative Antiretroviral Transcriptional Factor, OTK18

The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans

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