RRR-α-Vitamin E Succinate Potentiates the Antitumor Effect of Calcitriol in Prostate Cancer without Overt Side Effects

Yin, Yi; Ni, Jing; Chen, Ming; Guo, Yuxin; Yeh, Shuyuan

doi:10.1158/1078-0432.ccr-08-0910

Cited by 15 publications

(14 citation statements)

References 48 publications

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“…The VDR has been detected in the secretory-epithelial and stromal cells of the human prostate (6) and treatment of cells from the healthy prostate, from benign prostatic hypertrophy, and from prostate cancer with 1,25(OH) 2 D induces growth inhibition that is dependent upon the presence of the VDR (7, 8). In vivo , pharmacologic treatment with 1,25(OH) 2 D suppresses prostate tumor growth in models like Nkx3.1 +/− ; Pten +/− mice (9) and in mice with LNCaP (10) or PC3 (11) xenographs. However, the impact of dietary-induced alterations in serum 25OH D on prostate biology and cancer is less certain.…”

Section: Introductionmentioning

confidence: 99%

Dietary Vitamin D and Vitamin D Receptor Level Modulate Epithelial Cell Proliferation and Apoptosis in the Prostate

Kovalenko

Zhang

et al. 2011

Cancer Prevention Research

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Low vitamin D (VD) status may increase prostate cancer risk but experimental evidence for this relationship is modest. We tested whether low VD status or VD receptor (VDR) deletion influences prostate epithelial cell (PEC) biology using intact mice, castrated mice, or castrated mice treated with testosterone propionate (TP, 2.5 mg/kg BW). PEC proliferation (Ki-67 staining) and apoptosis (TUNEL method) were determined in the anterior prostate (AP). In study 1, wild-type (WT) and TgAPT121 mice (a model of prostate intraepithelial neoplasia) were fed diets with 25, 200 (reference diet), or 10000 IU VD/kg diet (as vitamin D3) prior to castration/repletion. Serum 25 hydroxyvitamin D levels were 26, 78, and 237 nmol/L in the three diet groups, respectively. Castration reduced proliferation and increased apoptosis in the AP while TP reversed these effects. Low VD diet increased proliferation in WT (+82%) and TgAPT121 (+24%) mice while it suppressed apoptosis in WT (−29%) and TgAPT121 (−37%) mice. This diet also increased the severity of PIN lesions in the AP of intact TgAPT121 mice. In study 2, mice with PEC-specific VDR deletion (PEC VDR KO) were examined after castration/repletion. TUNEL staining was 60% lower in castrated PEC VDR KO mice compared to castrated WT mice. In castrated mice given TP, Ki-67 staining was 2-fold higher in PEC VDR KO compared to WT mice. Our data show that low diet VDR or VDR deletion provide a prostate environment that is permissive to early procarcinogenic events that enhance prostate cancer risk.

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Section: Introductionmentioning

confidence: 99%

Dietary Vitamin D and Vitamin D Receptor Level Modulate Epithelial Cell Proliferation and Apoptosis in the Prostate

Kovalenko

Zhang

et al. 2011

Cancer Prevention Research

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“…For instance, it augments the effects of doxorubicin on prostate carcinoma cells [193], the effects of cisplatin, tamoxifen, and decaprazine on melanoma cells and parotid acinar carcinoma cells [194] and the effects of doxorubicin on leukemia cells [177]. Recently, combination of lowdosage calcitriol, a tumour suppressor of prostate cancer, and -TOS has been found to exert the similar or better chemotherapeutic efficacy without the overt side effects observed in high dosage of calcitriol treatment [195].…”

Section: Redox-active and Redox-silent Compounds Exert Different Modementioning

confidence: 99%

Redox-active and Redox-silent Compounds: Synergistic Therapeutics in Cancer

Tomasetti¹,

Santarelli²,

Alleva³

et al. 2015

CMC

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Tumours exhibit higher basal levels of reactive oxygen species (ROS) and altered redox environment compared to normal cells. Excessive level of ROS can be toxic to these cells, thus they become more vulnerable to damage by further ROS insults induced by pharmacological agents. However, the upregulation of antioxidant capacity in adaptation to intrinsic oxidative stress in cancer cells can confer drug resistance. Therefore, abrogation of such drug-resistant mechanisms by redox modulation could have significant therapeutic implications. Many redox-modulating agents have been developed. The redox-active system epitomised by ascorbate-driven quinone redox cycling, and the group of redox-silent vitamin E analogues represented by α-tocopheryl succinate have been shown to induce selective cancer cell death in different types of cancer. These compounds synergistically act by destabilising organelles like mitochondria, unleashing their apoptogenic potential, which results in efficient death of malignant cells and suppression of tumour growth. Consistent with this notion, clinical trials that aim to examine the therapeutic performance of novel redox-modulating drugs in cancer patients are currently under way.

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“…In addition, α-TOS selectively kills tumor cells without toxic effects on normal cells, such as intestinal epithelial cells, prostate cells and hepatocytes [69,78]. α-TOS can suppress tumor growth both alone and in combination with chemotherapy and/or radiation [79–81]. In vitro , α-TOS demonstrated enhanced cytotoxicity towards prostate cancer cells via additive or synergistic effects with DOX [80].…”

Section: Dual-function Micellar Systemmentioning

confidence: 99%

“…In vitro , α-TOS demonstrated enhanced cytotoxicity towards prostate cancer cells via additive or synergistic effects with DOX [80]. Treatment with low-dose calcitriol combined with α-TOS was significantly superior to the additive effect of each treatment in cultured prostate cancer cells and in animal models of prostate cancer [81]. α-TOS also synergized with PTX in inhibiting the growth of bladder cancer cells in vitro and in vivo through inhibiting the activation of NF-κB [82].…”

Section: Dual-function Micellar Systemmentioning

confidence: 99%

Nanomicellar Carriers for Targeted Delivery of Anticancer Agents

Zhang

Huang

2013

Ther. Deliv.

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Clinical application of anticancer drugs is limited by problems such as low water solubility, lack of tissue-specificity and toxicity. Formulation development represents an important approach to these problems. Among the many delivery systems studied, polymeric micelles have gained considerable attention owing to ease in preparation, small sizes (10–100 nm), and ability to solubilize water-insoluble anticancer drugs and accumulate specifically at the tumors. This article provides a brief review of several promising micellar systems and their applications in tumor therapy. The emphasis is placed on the discussion of the authors’ recent work on several nanomicellar systems that have both a delivery function and antitumor activity, named dual-function drug carriers.

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RRR-α-Vitamin E Succinate Potentiates the Antitumor Effect of Calcitriol in Prostate Cancer without Overt Side Effects

Cited by 15 publications

References 48 publications

Dietary Vitamin D and Vitamin D Receptor Level Modulate Epithelial Cell Proliferation and Apoptosis in the Prostate

Dietary Vitamin D and Vitamin D Receptor Level Modulate Epithelial Cell Proliferation and Apoptosis in the Prostate

Redox-active and Redox-silent Compounds: Synergistic Therapeutics in Cancer

Nanomicellar Carriers for Targeted Delivery of Anticancer Agents

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