2018
DOI: 10.1002/jcp.27485
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Rs217727 polymorphism in H19 promotes cell apoptosis by regulating the expressions of H19 and the activation of its downstream signaling pathway

Abstract: Background:The objective of the current study was to explore the role of H19 rs217727 polymorphism in the control of hepatocellular carcinoma (HCC). Method: The Student's t test, Cox regression, and Kaplan-Meier analyses were used to clarify whether the H19 rs217727 polymorphism played an important role in the development of HCC. Real-time polymerase chain reaction (PCR) and western-blot analysis were carried out to measure the levels of H19, microRNA (miR)-675, FAS-associated death domain (FADD), caspase-8, a… Show more

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Cited by 14 publications
(13 citation statements)
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“…Recent study suggested that knockdown of H19 expression which regulated the CDC42/PAK1 pathway could inhibit cell growth, migration, invasion, and promote apoptosis through miR‐15b in HCC cells and tissues 2 . Moreover, reduced expression of H19 could induce cell apoptosis in HCC cells and other cancer cells 1,35 . Apparently, our result also suggested knockdown of H19 expression induced apoptosis which further confirmed the previous findings.…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Recent study suggested that knockdown of H19 expression which regulated the CDC42/PAK1 pathway could inhibit cell growth, migration, invasion, and promote apoptosis through miR‐15b in HCC cells and tissues 2 . Moreover, reduced expression of H19 could induce cell apoptosis in HCC cells and other cancer cells 1,35 . Apparently, our result also suggested knockdown of H19 expression induced apoptosis which further confirmed the previous findings.…”
Section: Discussionsupporting
confidence: 89%
“…HCC is the most cause of cancer deaths which was malignancy in liver. Long non‐coding RNAs (lncRNAs) have been identified as an effective modulator of carcinogenesis; besides, abnormal expression of lncRNAs has been related to the initiation, progression, and metastasis in HCC 1,2 . Indeed, lncRNA H19 , a paternally imprinted gene, is recognized to have a key role in the carcinogenic process 3 .…”
Section: Introductionmentioning
confidence: 99%
“…In fact, in colorectal cancer, IGF2 expression is unrelated to its imprinting status [100], which might be also the case also for H19. n = 359 n = 1190 controls -gene polymorphisms and specific haplotype of H19 increased susceptibility to hepatocellular carcinoma [87] n = 944 -rs2839698 SNP of lncRNA-H19 was associated with an increased risk of HCC [102] n = 214 -polymorphism of rs217727 in H19 was associated with HCC [101] Two other exciting studies investigate the association between different H19 polymorphisms and the susceptibility as well as prognosis on tumorigenesis [86,87]. A study in glioma by Deng et al with 605 patient samples showed that some polymorphisms decreased susceptibility to glioma, a common and highly fatal brain tumor [86].…”
Section: The Role Of H19 Ex Vivo-human Samplesmentioning
confidence: 99%
“…But so far, there is no evidence for a co-expression of H19 and HOTS in vivo [86]. In HCC, the T allele of H19 rs217727 polymorphism, which is associated with decreased H19 expression, enhanced the survival rate of patients with HCC [101]. However, the study from Wu et al showed a correlation between H19 gene polymorphisms and the susceptibility to develop late-stage tumors [87].…”
Section: The Role Of H19 Ex Vivo-human Samplesmentioning
confidence: 99%
“…However, the up-regulated expression of the H19 gene can inhibit pituitary tumor cell proliferation in vitro and in vivo [21]. Consistently, H19 gene expression decreased in most hepatoblastomas [22]. Studies have shown that epigenetic errors at the H19 gene site in early embryonic development may result in the silencing of the double-alleles in Wilms tumor, thereby affecting the imprinting of parental alleles [23].…”
Section: Introductionmentioning
confidence: 94%