Ru-catalyzed direct arene C–H amidation of pyrrolo[2,3-d]pyrimidines with sulfonyl azides

Photoinduced arylation or alkylation of 1,2,4-triazine-3,5(2H,4H)-diones with hydrazines

“…Drawing from these experimental observations and insights from previous literature, 4 b ,8,9 we proposed a plausible reaction mechanism, outlined in Scheme 6. Initially, under irradiation with blue LED light, O 2 is excited to form .…”

Ruthenium-catalysed direct C–H amidation of 4-aryl-pyrrolo[2,3-d]pyrimidines with acyl/phosphoryl azides

“…Pyrrolo[2,3- d ]pyrimidines (7-deazapurines) are one of the major classes of fused heterocycles with various biological activities such as anticancer, 5–7 antibacterial, 8 antifungal and anti-inflammatory. 9 With the rapid development of C–H functionalization methodologies, the derivatization of pyrrolo[2,3- d ]pyrimidines was widely studied including borylation, 10 sulfenylation, 11 sulfonamidation, 12 fluoroalkoxylation, 13 arylation 14 and acetoxylation. 15…”

Visible-Light-Induced Highly Site-Selective Direct C–H Phosphorylation of Pyrrolo[2,3-d]pyrimidine Derivatives with H-Phosphine Oxides

“…Owing to their high biological activities, our group is also actively involved in the late-stage of pyrrolo[2,3- d ]pyrimidines. In our previous work, we have developed Pd-catalyzed C–H arylation, C–H mono- and bis-acetoxylation, and Ru-catalyzed C–H amidation of pyrrolo[2,3- d ]pyrimidine derivatives. In the continuation of further functionalization of pyrrolo[2,3- d ]pyrimidine, herein, we will report a visible-light-induced highly regioselective C–H phosphorylation of pyrrolo[2,3- d ]pyrimidine derivatives with various H-phosphine oxides promoted by dilauroyl peroxide (LPO) at room temperature (Scheme d).…”