Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells

Marques, Joana; Silva, V.L.M.; Silva, A.M.S.; Marques, M. P. M.; Braga, Susana S.

doi:10.1080/2164232x.2013.873992

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Pyrazoles have attracted increased attention in recent years owing to their widespread applications in medicine [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], agriculture, [ 16 ] materials science [ 17 , 18 , 19 , 20 ], and catalysis [ 21 , 22 ]. In this review, the chemistry of a particular kind of pyrazoles, the vinylpyrazoles, is revisited.…”

Section: Introductionmentioning

confidence: 99%

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Silva

2022

Molecules

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Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecules. Concerning the reactivity of vinylpyrazoles, the topics surveyed herein include their use in cycloaddition reactions, free-radical polymerizations, halogenation and hydrohalogenation reactions, and more recently in transition-metal-catalyzed reactions, among other transformations. The current state of the art about vinylpyrazoles is presented with an eye to future developments regarding the chemistry of these interesting compounds. Styrylpyrazoles were not considered in this review, as they were the subject of a previous review article published in 2020.

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Section: Introductionmentioning

confidence: 99%

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Silva

2022

Molecules

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“…Following our interest in the synthesis and biological evaluation of pyrazole-type compounds envisaging their use in medicine [9][10][11][12][13][14] and considering their huge potential for application in PET field, herein we present an overview of pyrazole-derived PET radiotracers developed in the last 20 years. Pyrazoles labeled with 18 F radionuclide will be the focus of this review article, given the aforementioned advantages of this radionuclide for routine PET imaging.…”

Section: Introductionmentioning

confidence: 99%

Pyrazoles as Key Scaffolds for the Development of Fluorine-18-Labeled Radiotracers for Positron Emission Tomography (PET)

Gomes

Silva

2020

Molecules

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The need for increasingly personalized medicine solutions (precision medicine) and quality medical treatments, has led to a growing demand and research for image-guided therapeutic solutions. Positron emission tomography (PET) is a powerful imaging technique that can be established using complementary imaging systems and selective imaging agents—chemical probes or radiotracers—which are drugs labeled with a radionuclide, also called radiopharmaceuticals. PET has two complementary purposes: selective imaging for diagnosis and monitoring of disease progression and response to treatment. The development of selective imaging agents is a growing research area, with a high number of diverse drugs, labeled with different radionuclides, being reported nowadays. This review article is focused on the use of pyrazoles as suitable scaffolds for the development of 18F-labeled radiotracers for PET imaging. A brief introduction to PET and pyrazoles, as key scaffolds in medicinal chemistry, is presented, followed by a description of the most important [18F]pyrazole-derived radiotracers (PET tracers) that have been developed in the last 20 years for selective PET imaging, grouped according to their specific targets.

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Supramolecular adducts of native and permethylated β-cyclodextrins with (2,2′-dipyridylamine)chlorido(1,4,7-trithiacyclononane)ruthenium(II) chloride: solid-state and biological activity studies

et al. 2017

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The complex [([9]aneS 3 )Ru II (dipa)Cl]Cl (1, where dipa = 2,2 0 -dipyridylamine) was included into native b-cyclodextrin (b-CD) and permethylated b-CD (TRIMEB) by co-dissolution followed by solvent removal. Two adducts were obtained with a 1:1 host:guest stoichiometry. Solid-state studies of the guest comprised collecting the single-crystal structure of its 3.5 hydrate form and also powder diffraction on the remaining bulk material, showing it is isotypical with the harvested crystal for X-ray analysis. Solid-state studies of the cyclodextrin adducts were carried out by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), 13 C{ 1 H} CP/MAS NMR and FTIR spectroscopies. Biological studies on 1 and its adducts comprised the evaluation of the shift caused by 1 on the melting temperature of DNA (DT m ), as well as the evaluation of cytotoxicity by the MTT assay on the osteosarcoma MG-63 cell line. 1414MG-63 cell line. m, 1356MG-63 cell line. m, 1337MG-63 cell line. m, 1299MG-63 cell line. m, 1273MG-63 cell line. w, 1261MG-63 cell line. w, 1240MG-63 cell line. m, 1159 s, 1123 m, 1080 s, 1027 vs, 1000 s, 947 m, 935 m, 910 w, 848 m, 827 w, 775 m, 763 m, 709 m, 609 m, 576 m, 532 m, 440 w, 420 w, 402 w, 369 vw, 355 vw, 335 vw, 329 vw, 324 vw, 303 w, 289 w.

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Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells

Cited by 6 publications

References 15 publications

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Pyrazoles as Key Scaffolds for the Development of Fluorine-18-Labeled Radiotracers for Positron Emission Tomography (PET)

Supramolecular adducts of native and permethylated β-cyclodextrins with (2,2′-dipyridylamine)chlorido(1,4,7-trithiacyclononane)ruthenium(II) chloride: solid-state and biological activity studies

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