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ISSN: (Print) 2164-232X (Online) Journal homepage: http://www.tandfonline.com/loi/tcme20 Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells J. Marques, V.L.M. Silva, A.M.S. Silva, M.P.M. Marques & S.S. Braga To cite this article: J. Marques, V.L.M. Silva, A.M.S. Silva, M.P.M. Marques & S.S. Braga (2014) Ru(II) trithiacyclononane 5-(2-hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole], a complex with facile synthesis and high cytotoxicity against PC-3 and MDA-MB-231 cells, Complex Metals, 1:1, 7-12, The ruthenium(II) complex [Ru([9]aneS 3 )(phpz)Cl 2 ] (1) ([9]aneS 3 = trithiacyclononane, phpz = 5-(2hydroxyphenyl)-3-[(4-methoxystyryl)pyrazole]) was readily isolated by reacting [Ru([9]aneS 3 )(DMSO)Cl 2 ] with one equivalent of the ligand phpz. A combination of MS, FT-IR and solution NMR studies (1-D and 2-D) was employed to determine the structural formula of the complex 1, in which phpz coordinates in a monodentate mode to Ru(II) by a simple replacement of the leaving group DMSO of the precursor. The cytotoxic properties of 1 in vitro were investigated by determination of the half-maximal growth inhibition on the human prostate (PC-3) and breast cancer cells (MDA-MB-231).