Rubella antibody loss rates in Korean children

Ki, Moran; Kim, M. H.; Choi, Bo-Youl; Shin, Young-jeon; Park, Tansol

doi:10.1017/s0950268802007811

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…Susceptibility rates were different by gender, which can be attributed to the immunologic effect. In our study, rubella immune loss rate during 3 yr was observed more frequently among boys (24). In the rubella epidemic of Korea in 1996, among 5 to 14 yr old, the incidence rate of boys (55/100,000) was higher than that of girls (19/100,000).…”

Section: Discussionsupporting

confidence: 41%

Rubella Seroprevalence in Korean Children

Choi

Kim

et al. 2003

J Korean Med Sci

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The aim of this study was to determe the age-specific rubella seroprevalence and the related factors in Korean children. Subjects of the study were 5,393 students from 8 elementary schools in Gyeonggi Province, Korea. Questionnaire surveys with blood sampling were conducted in 1993, 1996, and 1999. ELISA tests, used to detect rubella specific IgG antibody, were Imx (Abbott, U.S.A.) in 1993 and 1999, and Enzygnost (Behring, Germany) in 1996. The age-adjusted rubella susceptibility rate was 22.9% (95% CI: 22.8-23.0%) and it increased with age from 14% to 28%. The susceptibility rates of vaccinees, nonvaccinees, and the unknown group were 21%, 35%, and 27%, respectively (p=0.000). The rates by parental education levels for elementary and below, middle school, high school, and college and over were 37%, 26%, 24%, and 20%, respectively. The geometric mean titers (GMTs) of nonvaccinees, the unknown group, and vaccinees were 47 IU/mL, 42 IU/mL, and 37 IU/mL, respectively (p=0.000). The susceptibility level was too high to prevent the rubella epidemic in Korea, which necessitates a programme that will enhance the coverage for 1st and 2nd MMR vaccination among school children. In particular, more attention should be paid to the vaccination of the children whose parental education level is relatively low.

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Section: Discussionsupporting

confidence: 41%

Rubella Seroprevalence in Korean Children

Choi

Kim

et al. 2003

J Korean Med Sci

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“…The seroprevalence of rubella in Korean populations was assessed previously in infants, children and adolescents 12–16. One study on 5393 students from eight elementary schools in the Gyeonggi province, Korea in 1993, 1996 and 1996 had reported that the age-adjusted rubella susceptibility rate was 22.9% 14.…”

Section: Discussionmentioning

confidence: 99%

“…One study on 5393 students from eight elementary schools in the Gyeonggi province, Korea in 1993, 1996 and 1996 had reported that the age-adjusted rubella susceptibility rate was 22.9% 14. Another study performed during the same study period had reported that rubella antibody loss rates were 14.3%–15.8% in Korean children 12. In a 2005 population-based survey in Nonsan, Korea, age-appropriate immunisation among urban-rural children aged 24–35 months had reported that the age-appropriate MMR immunisation rate was 61.1%–97.4% 16.…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been several studies on rubella in Korea, most of the studies have only been focused on surveillance of newly identified cases, seroprevalences of rubella IgG in children or had been conducted in the early 1990s 9 10 12–16. Although a recent meta-analysis assessing global seroprevalence of rubella among pregnant and childbearing age women, no data from Korean populations were included in the study 5.…”

Section: Introductionmentioning

confidence: 99%

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Recent trends in seroprevalence of rubella in Korean women of childbearing age: a cross-sectional study

Choi¹,

et al. 2020

BMJ Open

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ObjectivesThe aim of this study was to investigate the immunity against rubella using the serological status of rubella-specific IgG antibodies (antirubella IgG) in Korean women of childbearing age (15–49 years).DesignRetrospective cross-sectional study.SettingPopulation-based cross-sectional study in South Korea.ParticipantsBetween January 2010 and December 2017, test results from Korean women aged 15–49 years who had visited an obstetric private clinic (nationwide institutions) and had requested rubella-specific IgG antibody tests from Green Cross Laboratories were obtained from the laboratory information system.ResultsBetween 2010 and 2017, antirubella IgG test results from 328 426 Korean women aged 15–49 years who had visited private obstetric clinics (1438 institutions nationwide) were retrospectively analysed by tested year, age, cohort and geographic regions. Over the 8-year study period, the rate of unimmunised women ranged from 7.8% to 9.7%. Multivariable-adjusted logistic regression models showed that the odds of being immune to rubella (positive and equivocal results of antirubella IgG test) were lower in 2017 compared with 2010, in women in their 40s, in a pre-catch-up cohort and in women living in Incheon, Busan, South Gyeongsang, North and South Jeolla and Jeju provinces (p<0.0001).ConclusionsIn consideration of the factors associated with prevalence of women unimmunised to rubella, future public health efforts should be focused on catch-up activities. The results of this study could be used to strengthen disease control and prevent rubella, including a nationwide immunisation programme.

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“…We and others have consistently found antibody response dynamics and patterns following rubella vaccination that depended on rubella-specific pre-immunization titer and the propensity of the individual to respond to vaccination [7,15,16,38]. The same holds true for the measles component of the MMR vaccine, where seronegativity and low antibody titer following previous vaccination were demonstrated to be a significant risk factor for persistent low antibody titer and/or seronegativity after a subsequent dose of MMR [39][40][41][42].…”

Section: Discussionmentioning

confidence: 53%