Rubella in the People's Republic of China

Wannian, Su

doi:10.1093/clinids/7.supplement_1.s72

Cited by 6 publications

(3 citation statements)

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“…The greatest uncertainty in the regional CRS incidence per 100,000 Iivebirths, weighted by the population size and the regional or global number of CRS cases in 2010 was associated with the dataset from China[ 27 ] (Figs K-M in S1 File ). For example, excluding any single dataset, excepting that for China, scarcely affected these statistics.…”

Section: Resultsmentioning

confidence: 99%

“…Calculations of the CRS incidence for the Western Pacific excluded China, where the prevaccination incidence was considerably lower than elsewhere in the region, resulting from the high force of infection and high seropositivity (98%—see Table I in S1 File ) among adolescents during 1979–80[ 27 ]. Even before RCV was introduced in 2008, the epidemiology of rubella in China may have changed since 1979–80, as suggested by high (25%) levels of susceptibility seen recently among female migrant workers in Shenzen in China[ 37 ], possibly resulting from demographic changes and vaccination in the private sector.…”

Section: Discussionmentioning

confidence: 99%

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Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review

et al. 2016

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BackgroundThe burden of Congenital Rubella Syndrome (CRS) is typically underestimated in routine surveillance. Updated estimates are needed following the recent WHO position paper on rubella and recent GAVI initiatives, funding rubella vaccination in eligible countries. Previous estimates considered the year 1996 and only 78 (developing) countries.MethodsWe reviewed the literature to identify rubella seroprevalence studies conducted before countries introduced rubella-containing vaccination (RCV). These data and the estimated vaccination coverage in the routine schedule and mass campaigns were incorporated in mathematical models to estimate the CRS incidence in 1996 and 2000–2010 for each country, region and globally.ResultsThe estimated CRS decreased in the three regions (Americas, Europe and Eastern Mediterranean) which had introduced widespread RCV by 2010, reaching <2 per 100,000 live births (the Americas and Europe) and 25 (95% CI 4–61) per 100,000 live births (the Eastern Mediterranean). The estimated incidence in 2010 ranged from 90 (95% CI: 46–195) in the Western Pacific, excluding China, to 116 (95% CI: 56–235) and 121 (95% CI: 31–238) per 100,000 live births in Africa and SE Asia respectively. Highest numbers of cases were predicted in Africa (39,000, 95% CI: 18,000–80,000) and SE Asia (49,000, 95% CI: 11,000–97,000). In 2010, 105,000 (95% CI: 54,000–158,000) CRS cases were estimated globally, compared to 119,000 (95% CI: 72,000–169,000) in 1996.ConclusionsWhilst falling dramatically in the Americas, Europe and the Eastern Mediterranean after vaccination, the estimated CRS incidence remains high elsewhere. Well-conducted seroprevalence studies can help to improve the reliability of these estimates and monitor the impact of rubella vaccination.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review

et al. 2016

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“…The literature concerning the prevention and the protective efficacy of the rubella vaccine reveals a world wide unity of purpose. However, enormous variance in strategies and clinical effects has been reported (17,19,20,23,25,26,28,34,35,36,39,42).…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology, morbidity and vaccination strategies against rubella infection. Eight years experience in oltrepo pavese

et al. 1993

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Selective rubella vaccination of schoolgirls in Italy started 14 years ago following the United Kingdom strategy that was adopted in 1970. The aims of this program were to eliminate the risk of rubella among women of childbearing age, encourage the acquisition of immunity by natural infection during early childhood and allow the vaccine-induced antibody production by the circulating virus. On the basis of this program, between 1982 to 1990, a prospective serosurvey for rubella antibody in the province of Pavia was performed. The results showed a decline in the overall seropositivity rate for rubella antibodies from 57.7% in 1982 to 41.9% in 1984 followed by a remarkable increase in 1985 (53.3%) and in 1987 (56.5%). This trend was confirmed by the number of cases reported to the local Public Health Service. The results of this study provide further evidence of the need to change the current selective immunization policy in order to obtain a significant reduction of risk of the infection in the population.

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The predicted impact of private sector MMR vaccination on the burden of Congenital Rubella Syndrome

Vynnycky

Cutts

2003

Vaccine

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Rubella in the People's Republic of China

Cited by 6 publications

References 0 publications

Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review

Using Seroprevalence and Immunisation Coverage Data to Estimate the Global Burden of Congenital Rubella Syndrome, 1996-2010: A Systematic Review

Seroepidemiology, morbidity and vaccination strategies against rubella infection. Eight years experience in oltrepo pavese

The predicted impact of private sector MMR vaccination on the burden of Congenital Rubella Syndrome

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