Rubella seroprevalence in pregnant women in North Thames: estimates based on newborn screening samples

Hardelid, Pia; Cortina‐Borja, Mario; Williams, D. Innes; Tookey, P; Peckham, Catherine; Cubitt, W. D.; Dezateux, Carol

doi:10.1258/jms.2009.008080

Cited by 14 publications

(7 citation statements)

References 31 publications

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“…The incidence of acute hepatitis in Amsterdam was higher among first-generation migrants compared with the Dutch population [26]. In the study conducted to UK-born women [56]. In Germany, 2.2% of 678 newly arrived refugees were seronegative [40].…”

Section: Hepatitis B Virusmentioning

confidence: 88%

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Vaccinations in migrants and refugees: a challenge for European health systems. A systematic review of current scientific evidence

Mipatrini¹,

Stefanelli

Severoni

et al. 2017

Pathogens and Global Health

171

122

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The decline of immunization rates in countries of origin of migrants and refugees, along with risky conditions during the journey to Europe, may threaten migrants' health. We performed a systematic review of the scientific literature in order to assess the frequency of vaccine preventable diseases, and vaccination coverage among migrants and refugees in Europe. To this end, Medline and Cochrane databases were considered. After the screening and the selection process, 58 papers were included in the review. We focused on the following vaccinepreventable diseases: hepatitis B, measles, rubella, mumps, tetanus, poliomyelitis, pertussis, diphtheria, meningitis, and varicella. The results were presented as a qualitative synthesis. In summary, several studies highlighted that migrants and refugees have lower immunization rates compared to European-born individuals. Firstly, this is due to low vaccination coverage in the country of origin. Then, several problems may limit migrants' access to vaccination in Europe: (i) migrants are used to move around the continent, and many vaccines require multiple doses at regular times; (ii) information on the immunization status of migrants is often lacking; (iii) hosting countries face severe economic crises; (iv) migrants often refuse registration with medical authorities for fear of legal consequences and (v) the lack of coordination among public health authorities of neighboring countries may determine either duplications or lack of vaccine administration. Possible strategies to overcome these problems include tailoring immunization services on the specific needs of the target population, developing strong communication campaigns, developing vaccination registers, and promoting collaboration among public health authorities of European Countries. Background and aims

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Section: Hepatitis B Virusmentioning

confidence: 88%

“…Studies conducted in Sweden and in the UK showed that migrant women were less likely to be immunized for rubella than native women; in the former group, 10% were found to be seronegative [55,56]. In particular, odd ratios of 4.2 and 5.0 were found for women born in SubSaharan Africa and in South Asia, respectively, compared…”

Section: Measles Mumps and Rubellamentioning

confidence: 96%

Vaccinations in migrants and refugees: a challenge for European health systems. A systematic review of current scientific evidence

Mipatrini¹,

Stefanelli

Severoni

et al. 2017

Pathogens and Global Health

171

122

View full text Add to dashboard Cite

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“…Unfortunately, our results also revealed a low catch‐up immunisation rate (17.7%) nationwide in women susceptible to rubella. Other studies have demonstrated that immigrant mothers were more likely to be seronegative to rubella, particularly those born in Africa and South Asia 23–25 . To reduce the incidence of congenital rubella in foreign‐born women, since 2002, immigrant women must present proof of rubella immunisation or positive tests for rubella antibodies when applying for temporary and permanent resident status in Taiwan 26 .…”

Section: Discussionmentioning

confidence: 99%

Rubella seroepidemiology and estimations of the catch-up immunisation rate and persistence of antibody titers in pregnant women in Taiwan

Shih

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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Objective To examine rubella seroepidemiology, and estimate rates of catch-up immunisation and persistence of antibody titers in pregnant women in Taiwan after mass immunisation.Design A retrospective study.Setting Two medical centres and four regional hospitals specialising in obstetric care. Main outcome measures Seronegativity, rate of catch-up immunization, and antibody decline.Results The seronegativity was 10.9% in all pregnant women. Immigrant women had higher seronegativity than indigenous women (OR 2.86; 95% CI 2.65, 3.01). Indigenous women born prior to implementation of the vaccination programmes were more susceptible (20.1%) to rubella infection than were women born thereafter (6.7%). Rates of seropositive conversion were low in both Taiwanese-born and foreign-born women (11.5 and 30.7%, respectively). The rubella antibody titers for vaccinated Taiwanese women in the 1971-1976 and after-1976 birth cohorts declined by 0.6 and 2.3% per year, respectively.Conclusions This study demonstrates high seronegativity of older indigenous and immigrant women, a low catch-up immunisation rate, and the persistence of rubella antibodies in Taiwan after mass vaccination. Our study suggests that a single dose of rubella vaccine in teenagers effectively increased rubella seropositivity during their childbearing years. This finding is useful for countries that lack the resources necessary for a two-dose regimen. We recommend free rubella antibody tests to women of childbearing age and free vaccination as required. All postpartum women testing negative for rubella antibodies should be vaccinated before they leave hospital.Keywords Catch-up immunization, congenital rubella syndrome (CRS), rubella.Please cite this paper as: Lin C, Yang C, Shih Y, Hsu H, Yang T, Cheng Y, Chang C, Hsieh L, Chen B, Lee C, Huang Y. Rubella seroepidemiology and estimations of the catch-up immunisation rate and persistence of antibody titers in pregnant women in Taiwan. BJOG 2011;118:706-712.

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“…Many of these women are likely to have come from rubella-endemic countries, with no or disrupted routine immunisation against rubella. A higher proportion of non-UK-born mothers, particularly those from sub-Saharan Africa and south-east Asia were more likely to be seronegative than UK-born women or white British women [ 23 ], [ 24 ] and analysis of antenatal rubella susceptibility data from London suggested that between 16% and 65% of non-UK-born women were susceptible in 2007 [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Rubella infection in pregnancy and congenital rubella in United Kingdom, 2003 to 2016

et al. 2018

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Rubella vaccination has been included in the United Kingdom’s (UK) routine childhood schedule for nearly 30 years. The UK achieved World Health Organization (WHO) elimination status in 2016 and acute rubella infections are rare. In the period 2003–16, 31 rubella infections in pregnancy (0.23 per 100,000 pregnancies) were identified through routine surveillance, of which 26 were in women who were born abroad. Five of the 31 rubella infections led to congenital rubella syndrome in the infant and three had confirmed congenital rubella infection without congenital rubella syndrome. An additional seven babies were identified with congenital rubella syndrome, although rubella infection in pregnancy had not been reported. Place of birth was known for six of these seven mothers, all of whom were born outside the UK, and in five cases maternal infection was acquired abroad. WHO Europe has set targets for measles and rubella elimination and prevention of congenital rubella syndrome by 2015. Vaccination uptake and rubella immunity is high in the UK population and most infections in pregnancy since 2003 were acquired abroad and in unvaccinated women. Every contact with a health professional should be used to check that women are fully immunised according to UK schedule.

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Rubella seroprevalence in pregnant women in North Thames: estimates based on newborn screening samples

Abstract: Our findings highlight the need for vaccination to be targeted specifically at migrant women and their families to ensure that they are protected from rubella in pregnancy and its serious consequences.

Cited by 14 publications

References 31 publications

Vaccinations in migrants and refugees: a challenge for European health systems. A systematic review of current scientific evidence

Vaccinations in migrants and refugees: a challenge for European health systems. A systematic review of current scientific evidence

Rubella seroepidemiology and estimations of the catch-up immunisation rate and persistence of antibody titers in pregnant women in Taiwan

Rubella infection in pregnancy and congenital rubella in United Kingdom, 2003 to 2016

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