Rubella-vaccinated students. Follow-up in a public school system

Schiff, Gilbert M.; Rauh, Joseph L.; Young, Betsy; Trimble, Sally; Rotte, Tom; Schiff, Barbara E.

doi:10.1001/jama.240.24.2635

Cited by 10 publications

(1 citation statement)

References 15 publications

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“…Several studies have shown that vaccines induce long-lasting antibody responses of up to 23 years [2]. Many studies argue that the antibody loss rates differ with vaccine strains and study areas where wild rubella viruses circulate [3,4]. However, the difference was very small.…”

Section: Introductionmentioning

confidence: 99%

Rubella antibody loss rates in Korean children

Kim

Choi

et al. 2002

Epidemiol. Infect.

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We followed students in eight elementary schools for rubella antibody from 1993 to 1996 (602 pairs) and 1996-9 (588 pairs) in Gyeonggi Province, Korea. We tested rubella IgG and administered rubella vaccine to the children with the titres < 10 IU/ml. The loss rates of rubella IgG during the follow-up periods were 14.3 and 15.8%, respectively. Among vaccinated groups, the loss rate was 18.8%, which was significantly higher than 13.8% of the mixture of natural and vaccine-induced immunity groups. The group that had the lower preceding antibody titre had a higher loss rate of 24.8% compared to 7.2% for the group whose titre was 40 IU/ml or above. In a multivariate analysis, age and gender were not related to antibody loss rate. Under this higher rubella antibody loss rate, in order to prevent congenital rubella syndrome, the immunization for women at childbearing age appears necessary until rubella can be eliminated or controlled.

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Section: Introductionmentioning

confidence: 99%