Rubella-Virus Infection in Juvenile Rheumatoid Arthritis

Ogra, Pearay L.; Ogra, S.S.; Chiba, Yasuo; Dzierba, Judith L.; Herd, J. Kenneth

doi:10.1016/s0140-6736(75)93136-0

Cited by 73 publications

(22 citation statements)

References 22 publications

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“…They reported a 3-4-year cyclical pattern in the incidence of JRA, in which incidence peaks correlated with the incidence of Mycohactenum pneumoniae infections, based on serologic screening in 1979, 1982, 1986, and 1990-1991. Although variations in the incidence rate of JRA have been found in several studies, the peaks found in our cohort do not coincidc with those found in Gare's and Oens' studies (23). Thcsc differences may reflect multiple infectious agents or thc influence of geographic location or other environmental factors on JRA prescntation, or simply the natural variation of the disease.…”

Section: Discussioncontrasting

confidence: 77%

Juvenile rheumatoid arthritis in rochester, minnesota 1960–1993. Is the epidemiology changing?

Peterson

Mason

Nelson

et al. 1996

Arthritis & Rheumatism

114

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Objective. To examine trends in the incidence and prevalence of juvenile rheumatoid arthritis (JRA) in Rochester, Minnesota, over 33 years.Methods. The diagnostic retrieval system of the Rochester Epidemiology Project was utilized to screen medical records of all Rochester residents with any potential diagnoses of JRA from 1978 to 1993 (based on the American College of Rheumatology 1977 revised criteria). In addition, all cases of JRA from our previously identified cohort from 1960-1979 were verified, and the 2 data sets were combined, resulting in an incidence cohort spanning 33 years (1960-1993).Results. Of the 1,240 medical records screened, we identified 65 cases of JRA diagnosed between 1960 and 1993 (48 females, 17 males). The average followup for cases was 12.7 years (range 0-34 years) for a total of 833 person-years of observation. A bimodal distribution of age at diagnosis was observed, with peaks between 0 and 4 years and 9 and 15 years. Seventy-two percent of patients had pauciarticular-onset, 17% had polyarticularonset, and 11% had systemic-onset disease. Progression of pauciarticular to polyarticular disease occurred in 11% of the cases. The overall age-and sex-adjusted incidence rate was 11.7 per 100,000 population (95% confidence intervals 8.7, 14.8). The incidence rate per 100,000 population was 15.0, 14.1, and 7.8 for the time Supported in part hy research grants from the Arthritis Foundation (MAP 118) and the USPiIS, NII-I (AR-30582).

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Section: Discussioncontrasting

confidence: 77%

Juvenile rheumatoid arthritis in rochester, minnesota 1960–1993. Is the epidemiology changing?

Peterson

Mason

Nelson

et al. 1996

Arthritis & Rheumatism

114

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“…While viral infections have been implicated in several forms ofacute arthritis (1,2), their role in the etiology and/or pathogenesis of RA remains unclear (3). EBV (4)(5)(6)(7)(8), rubella (9,10), hepatitis B (1), vaccinia (11), and CMV (12,13) have been associated with RA, although the role ofviruses in the inflammatory process has resisted elucidation. Postulated mechanisms include (a) cross-reactivity between viral antigens and host tissue, (b) alteration of host tissue by virus rendering host tissue antigenic, and (c) chronic infection and/or destruction of host tissue directly leading to inflammation (2).…”

Section: Introductionmentioning

confidence: 99%

Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family.

Newkirk

Gram²,

Heinrich³

et al. 1988

J. Clin. Invest.

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The complete amino acid and nucleotide sequences of the variable regions of the heavy and light polypeptide chains of a human neutralizing IgGI anti-cytomegalovirus (CMV) antibody reveal a striking homology to IgM rheumatoid factors (RFs) of the Wa idiotypic family. The anti-CMV antibody and Wa RFs have in common VKIIIb, JKI, and VHIa gene segments but use different DH and JH gene segments. The anti-CMV antibody does not have RF activity and does not express the Wa idiotype. The Wa RFs do not have anti-CMV activity. A subset of Wa RFs, however, and the anti-CMV antibody do share several idiotypes on the VHIa and VKIIIb polypeptides. Since there are major differences in the antigen binding characteristics and some of the other expressed idiotypes, these data suggest that the D and J region amino acids are crucial to such specificities. Although the use of such highly homologous gene segments in different immune responses is well-documented in murine systems, these data represent the first such example in the human.

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“…However Ogra et a1 have demonstrated rubella virus antigen in synovial fluid from some children with juvenile rheumatoid arthritis (5). Studies of rubella antibody titers in patients with rheumatoid arthritis have generally shown no association (4,6-10).…”

mentioning

confidence: 99%

Chronic arthropathy associated with rubella vaccination

Spruance

Metcalf

Smith

et al. 1977

Arthritis & Rheumatism

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Eleven children suffered recurrent episodes of knee stiffness (“catcher's crouch syndrome”) after receiving HPV‐77DK12 rubella vaccine. One was evaluated by arthroscopy and the synovium was found to be hypertrophied posteriorly and to protrude in folds into the intercondylar notch and lateral joint space. Culture for rubella virus was unsuccessful. The authors' observations provide evidence that “catcher's crouch syndrome” is a synovial disease and that chronic joint disease can be a sequela of rubella immunization.

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Rubella-Virus Infection in Juvenile Rheumatoid Arthritis

Cited by 73 publications

References 22 publications

Juvenile rheumatoid arthritis in rochester, minnesota 1960–1993. Is the epidemiology changing?

Juvenile rheumatoid arthritis in rochester, minnesota 1960–1993. Is the epidemiology changing?

Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family.

Chronic arthropathy associated with rubella vaccination

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