Rückfallraten innerhalb von 6 Monaten nach erfolgreicher EKT: Eine naturalistische prospektive Fremd- und Selbstbeurteilungsanalyse

Does lithium prevent relapse following successful electroconvulsive therapy for major depression? A systematic review and meta‐analysis

“…33 Patients with bipolar depression were excluded in seven studies, 12,18,20,[29][30][31]34,35 six studies comprised patients with unipolar as well as bipolar depression, 32,33,[36][37][38][39] and one study included patients with bipolar depression only. 19 Ten of the included studies were prospective 12,[18][19][20]29,30,[34][35][36][37][38] and four had a retrospective design in the continuation phase. [31][32][33]39 Three studies had an interventional design, 12,29,30,34 eleven of them were observational.…”

“…33 In eight studies, continuation treatment in the group using lithium consisted of lithium monotherapy or lithium plus either antidepressant(s), or antipsychotic(s), or mood stabilizer(s), or C-ECT, or a combination. [18][19][20]32,[36][37][38][39] 4.2 | Quality assessment One randomized study 12 was at low risk of bias, whereas 2 randomized studies 29,34 were at unclear risk of bias. Two cohort studies 31,37 received moderate and 9 cohort studies [18][19][20]32,33,35,36,38,39 received high (i.e., low risk of bias) scores on the NOS.…”

“…[18][19][20]32,[36][37][38][39] 4.2 | Quality assessment One randomized study 12 was at low risk of bias, whereas 2 randomized studies 29,34 were at unclear risk of bias. Two cohort studies 31,37 received moderate and 9 cohort studies [18][19][20]32,33,35,36,38,39 received high (i.e., low risk of bias) scores on the NOS. Overall, 10 of 14 (71.43%) included studies were at low risk of bias.…”

“…[29][30][31][32] Mean age of study participants ranged from 51.0 to 69.8 years and was not reported in one study. 33 Patients with bipolar depression were excluded in seven studies, 12,18,20,[29][30][31]34,35 six studies comprised patients with unipolar as well as bipolar depression, 32,33,[36][37][38][39] and one study included patients with bipolar depression only. 19 Ten of the included studies were prospective 12,[18][19][20]29,30,[34][35][36][37][38] and four had a retrospective design in the continuation phase.…”

“…[31][32][33]39 Three studies had an interventional design, 12,29,30,34 eleven of them were observational. [18][19][20][31][32][33][35][36][37][38][39] In six studies, at least one of the relapse criteria was based on clinical judgment or a cutoff score on a depression rating scale. 12,[34][35][36][37][38] Follow-up duration ranged from 15 to 58 weeks (median = 26) and was not reported in one study.…”