Rules of anti-infection therapy for sepsis and septic shock

Abstract

Objective:Sepsis is a deadly infection that causes injury to tissues and organs. Infection and anti-infective treatment are the eternal themes of sepsis. The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. This evidence is combined with clinical experiments to reveal the rules and a standard flowchart of anti-infection therapy for sepsis.Data Sources:We retrieved information from the PubMed database up to October 2018 using various search terms and their combinations, including sepsis, septic shock, infection, antibiotics, and anti-infection.Study Selection:We included data from peer-reviewed journals printed in English on the relationships between infections and antibiotics.Results:By combining the literature review and clinical experience, we propose a 6Rs rule for sepsis and septic shock management: right patients, right time, right target, right antibiotics, right dose, and right source control. This rule encompasses rational decisions regarding the timing of treatment, the identification of the correct pathogen, the selection of appropriate antibiotics, the formulation of a scientifically based antibiotic dosage regimen, and the adequate control of infectious foci.Conclusions:This review highlights how to recognize and treat sepsis and septic shock and provides rules and a standard flowchart for anti-infection therapy for sepsis and septic shock for use in the clinical setting.

The burden and costs of sepsis and reimbursement of its treatment in a developing country: An observational study on focal infections in Indonesia

“…The incidence of sepsis associated with multifocal infections remains unknown, particularly in developing countries, but it was found that they are the costliest. Identifying multisource infections with sepsis prior to the occurrence of organ dysfunction is thus an urgent task (Zhou et al 2019).…”

Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells

“…CYP1A1 metabolizes the class III antiarrhythmic drug amiodarone to desethyl amiodarone, the latter causes toxicity in multiple organs (Wu et al, 2016). Another substrate of CYP1A1 is the macrolide erythromycin used as an antiinfection agent or for gastrointestinal disease in ICUs (Zhou et al, 2019). Overexpression of CYP1A1 by Wnt5A may enhance erythromycin's metabolism and thus affects its half-life leading to the persistence of infection and lack of drug efficiency.…”

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