Rules of Meridians and Acupoints Selection in Treatment of Parkinson's Disease Based on Data Mining Techniques

Li, Zhe; Hu, Yingyu; Zheng, Chunye; Q, Su; Chang, An; Luo, Xiao‐Dong; Liu, Mao-Cai

doi:10.1007/s11655-017-2428-6

Cited by 14 publications

(8 citation statements)

References 4 publications

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“…It has been estimated that more than one-third of the patients with PD in the United States (40%) and the United Kingdom (38.7%) have already accepted at least one form of complementary and alternative medicine for PD, whereas 7%–10% of them have used acupuncture and moxibustion [13]. It was recently shown that moxibustion can postpone the progression of PD and decrease the symptom severity [14, 15]. Additionally, it has been shown to enhance the protective effect of dopamine neurons in patients with PD [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Lü

Liu

Tian

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The objective of this study was to explore the neuroprotective effect of moxibustion on rats with Parkinson’s disease (PD) and its mechanism. A Parkinson’s disease model was established in rats using a two-point stereotactic 6-hydroxydopamine injection in the right substantia nigra (SN) and ventral tegmental area. The rats received moxibustion at the Baihui (GV20) and Sishencong (EX-HN1) acupoints for 20 minutes, six times a week, for 6 weeks. The right SN tissue was histologically and immunohistochemically examined. Differentially expressed genes (DEGs) were identified through RNA sequencing. In addition, the levels of tyrosine hydroxylase (TH), glutathione peroxidase 4 (GPX4), and ferritin heavy chain 1 (FTH1) in SN were measured. In comparison to the model group, the moxibustion group showed a significantly greater TH immunoreactivity and a higher behavioural score. In particular, moxibustion led to an increase in the number and morphological stability of SN neural cells. The functional pathway analysis showed that DEGs are closely related to the ferroptosis pathway. GPX4 and FTH1 in the SN were significantly overexpressed in the moxibustion-treated rats with PD. Moxibustion can effectively reduce the death of SN neurons, decrease the occurrence of ferroptosis, and increase the TH activity to protect the neurons in rats with PD. The protective mechanism may be associated with suppression of the ferroptosis.

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Section: Introductionmentioning

confidence: 99%

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Lü

Liu

Tian

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Another important finding of this study is that moxibustion treatment of Shi's moxa stick can effectively suppress dopaminergic neurons' death. As a form of external therapy in traditional Chinese medicine, moxibustion treatment reported can ameliorate motor symptoms in PD patients [9,10]. Shi's moxa sticks were developed by Shi Xuemin, an academician of the Chinese Academy of Engineering and a master of traditional Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

“…Moxibustion is a form of external therapy in traditional Chinese medicine [8]. Recent research suggested that moxibustion treatment can postpone PD progression and has an apparent therapeutic effect on motor symptom improvement in PD patients [9,10]. Moreover, numerous animal experiments have confirmed that moxibustion can alleviate PD injury.…”

Section: Introductionmentioning

confidence: 99%

Moxibustion Protects Dopaminergic Neurons in Parkinson’s Disease through Antiferroptosis

Huang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson’s disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxidase 4 (GPX4) and Ferritin Heavy Chain 1 (FTH1), the level of reactive oxygen species (ROS), and the morphology of mitochondrial were detected to evaluate the level of ferroptosis. The results showed that moxibustion treatment of Shi’s moxa sticks could reduce the behavioral score, alleviate the level of ferroptosis, decrease mitochondrial damage, and improve dopaminergic neuron survival. In conclusion, the present study results indicated that Shi’s moxa sticks could effectively suppress the level of ferroptosis, thereby improving the survival of dopaminergic neurons in the SNpc of PD rats, which may provide a promising complementary and alternative therapy for PD patients.

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“…Since acupuncture therapy is clinically practiced based on acupuncture point combinations, association rules analysis is suitable to investigate the underlying rules of acupuncture point selections. The previous studies using data mining methods revealed the core combinations of acupuncture points in treating various neurological disorders, such as Parkinson's disease (Li et al, 2020a), vascular dementia (Feng et al, 2015), and Alzheimer's disease (Yu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Combinations of scalp acupuncture location for the treatment of post-stroke hemiparesis: A systematic review and Apriori algorithm-based association rule analysis

et al. 2022

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BackgroundPost-stroke hemiparesis strongly affects stroke patients’ activities of daily living and health-related quality of life. Scalp acupuncture (SA) is reportedly beneficial for post-stroke hemiparesis. However, there is still no standard of SA for the treatment of post-stroke hemiparesis. Apriori algorithm-based association rule analysis is a kind of “if-then” rule-based machine learning method suitable for investigating the underlying rules of acupuncture point/location selections. This study aimed to investigate the core SA combinations for the treatment of post-stroke hemiparesis by using a systematic review and Apriori algorithm-based association rule analysis.MethodsWe conducted a systematic review to include relevant randomized controlled trial (RCT) studies investigating the effects of SA treatment in treating patients with post-stroke hemiparesis, assessed by the Fugl-Meyer Assessment (FMA) score. We excluded studies using herbal medicine or manual acupuncture.ResultsWe extracted 33 SA locations from the 35 included RCT studies. The following SA styles were noted: International Standard Scalp Acupuncture (ISSA), WHO Standard Acupuncture Point Locations (SAPL), Zhu’s style SA, Jiao’s style SA, and Lin’s style SA. Sixty-one association rules were investigated based on the integrated SA location data.ConclusionsSAPL_GV20 (Baihui), SAPL_GV24 (Shenting), ISSA_MS6_i (ISSA Anterior Oblique Line of Vertex-Temporal, lesion-ipsilateral), ISSA_MS7_i (ISSA Posterior Oblique Line of Vertex-Temporal, lesion-ipsilateral), ISSA_PR (ISSA Parietal region, comprised of ISSA_MS5, ISSA_MS6, ISSA_MS7, ISSA_MS8, and ISSA_MS9), and SAPL_Ex.HN3 (Yintang) can be considered the core SA location combination for the treatment of post-stroke hemiparesis. We recommend a core SA combination for further animal studies, clinical trials, and treatment strategies.

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Rules of Meridians and Acupoints Selection in Treatment of Parkinson's Disease Based on Data Mining Techniques

Abstract: The application of meridians and acupoints for PD treatment lay emphasis on the acupoints on the head, attach importance to extinguishing Gan wind, tonifying qi and blood, and nourishing sinews, and make good use of superior-inferior acupoints matching.

Cited by 14 publications

References 4 publications

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson’s Disease

Moxibustion Protects Dopaminergic Neurons in Parkinson’s Disease through Antiferroptosis

Combinations of scalp acupuncture location for the treatment of post-stroke hemiparesis: A systematic review and Apriori algorithm-based association rule analysis

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