Rupture of the ankle ligaments

Zwipp, H.; Hoffmann, R.; Thermann, Hajo; Wippermann, B.

doi:10.1007/bf00192302

Cited by 34 publications

(16 citation statements)

References 12 publications

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“…Ankle injury is a common pediatric injury that causes persistent pain, movement limitation, swelling and stiffness (33). Timely diagnosis, treatment and nursing care are very important for the reduction of pain and the healing of fractures.…”

Section: Discussionmentioning

confidence: 99%

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

et al. 2018

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Abstract. N-methyl pyrrolidone (NMP), a small bioactive molecule, has the potential to stimulate bone formation and inhibit osteoclast differentiation. The aim of the present study was to investigate the effect of NMP on the inflammatory response and underlying molecular mechanisms in MG-63 cells. The mRNA and protein expression of cytokines from peripheral blood in children with or without ankle fracture were determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and ELISA, respectively. MG-63 cells were pre-treated with/without NMP and stimulated with 1 µM bradykinin (BK). The production of cytokines from MG-63 cells was assessed by western blotting and RT-qPCR. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein were measured using western blotting and/or RT-qPCR. Western blotting was used to examine the activation level of mitogen activated protein kinase. Compared with healthy children, levels of tumor necrosis factor (TNF-α), interleukin (IL)-1β and IL-6 mRNA and protein were upregulated in children with ankle fracture. NMP treatment did not induce cytotoxicity in MG-63 cells. The BK-induced upregulation of TNF-α, IL-1β, IL-6, iNOS and COX-2 mRNA and protein was reversed in a dose-dependent manner by NMP. Furthermore, NMP downregulated the activation of c-Jun NH2-terminal kinase and p38 pathways, but not the extracellular signal-related kinase pathway. Therefore, the results of the current study demonstrate that NMP inhibits inflammation dependent on the mitogen-activated protein kinase pathway in MG-63 cells, indicating that it may be beneficial in the healing of fractures.

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Section: Discussionmentioning

confidence: 99%

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

et al. 2018

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“…The severity of acute ankle sprains can vary widely. They often result in persistent pain, limitations in movement, muscle weakness, swelling, stiffness, and absenteeism from work and/or sports participation (Hedges, ; Cetti, ; Zwipp et al., ; Yeung et al., ; Gerber et al., ; Verhagen et al., ; Hubbard & Hicks‐Little, ). Reinjuries and chronic ankle instability also can result from acute ankle sprains.…”

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confidence: 99%

Ankle injuries in the Netherlands: Trends over 10–25 years

Kemler

Port

Valkenberg

et al. 2014

Scandinavian Med Sci Sports

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Ankle injuries are a common health problem; data on ankle injury rates and time trends in the population at large are scarce. Our aim was to investigate the incidence of and time trends in population-based and emergency department-treated ankle injuries related to sports activities and other activities related to daily living. Data were obtained from one national survey on accidents and injuries (2000-2010) and one based on emergency department data (1986-2010). Linear regression was used to determine linear trends in ankle injuries per 1000 person-years. The number of ankle injuries related to sports activities and other activities of daily living increased from 19.0 to 26.6 per 1000 person-years (P = 0.002). The number of sports-related ankle injuries treated in emergency departments decreased from 4.2 to 1.5 per 1000 person-years (P < 0.001), and from 3.2 to 2.1 per 1000 person-years (P < 0.001) for other activities of daily living. According to our data, the incidence rates of all ankle injuries are around 5.5 times higher than those registered at emergency departments. The high incidence rates of ankle injuries highlight the need for proper ankle injury treatment and prevention.

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“…Conservative treatment is performed as usual and indications for operative treatment in acute injury do not differ. Furthermore chronic instability, second stage injuries and re-ruptures are normally indications for surgical treatment [9].…”

Section: Discussionmentioning

confidence: 99%

Upper ankle ligament rupture and long term problems in a patient with Ehlers Danlos Syndrome — a case report

et al. 2013

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AbstractRupture of the upper ankle joint ligaments is a common injury. Therapy in patients with Ehlers Danlos Syndrome (EDS) is a challenge due to the autosomal-dominant collagenopathy. Therapeutic recommendations and long term results in treatment of patients with EDS are rare. Therefore uncertainty exists. We present a case of clinical and radiologic long term results after ligament rupture of the upper ankle joint in a patient with EDS. A literature review tries to reveal current therapeutic strategies in patients with EDS.

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Rupture of the ankle ligaments

Cited by 34 publications

References 12 publications

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

Ankle injuries in the Netherlands: Trends over 10–25 years

Upper ankle ligament rupture and long term problems in a patient with Ehlers Danlos Syndrome — a case report

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