Ruptured Hepatic Epithelioid Angiomyolipoma: A Case Report and Literature Review

Tajima, Shogo; Suzuki, Akira; Suzumura, Kiyoshi

doi:10.1159/000363690

Cited by 17 publications

(10 citation statements)

References 16 publications

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“…Three cases with benign outcome had two high‐risk features (large size and necrosis). Similar findings have been reported in the literature, with two or more high‐risk features observed in AMLs with benign outcome . Vascular invasion has often been noted in AMLs with benign outcome .…”

Section: Discussionsupporting

confidence: 89%

“…Similar findings have been reported in the literature, with two or more high-risk features observed in AMLs with benign outcome. [30][31][32] Vascular invasion has often been noted in AMLs with benign outcome. 33,34 The lack of CD117 expression was postulated as a feature of malignancy based on one case; 10 however, CD117 was negative in all eight cases in our series with benign outcome.…”

Section: Discussionmentioning

confidence: 99%

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Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis

et al. 2018

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The predominance of epithelioid component resembling HCA or HCC is common in hepatic AML. Absence of LFABP and presence of fat can be mistaken for HNF1α-inactivated HCA. Diffuse GS staining can be mistaken for β-catenin-activated HCA or HCC. Diffuse GS expression is not related to CTNNB1 mutation. All tested cases showed TSC2 mutation, supporting this as the driving genetic event for hepatic AML.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis

et al. 2018

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“…Tumor size is also an important factor for predicting tumor rupture ( 9 ). To the best of our knowledge, the patient of case 3 is the 7th case of hepatic AML rupture that has been reported in the literature to date ( 11 ).…”

Section: Discussionmentioning

confidence: 98%

Hepatic epithelioid angiomyolipoma is a rare and potentially severe but treatable tumor: A report of three cases and review of the literature

et al. 2016

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Hepatic epithelioid angiomyolipoma (EAML) is a rare type of hepatic tumor. Due to a lack of adequate understanding about this tumor, hepatic EAML is often misdiagnosed as other diseases with similar clinical characteristics such as hepatic cancer. In the present study, 3 cases of hepatic EAML are reported, and the main clinicopathological features of this disease are presented, based on a literature search that included articles published in English between February 2000 and September 2014. A total of 24 hepatic EAML cases were considered, of which, 17 were females and 4 presented multiple liver lesions. Among the patients with single lesions, 2 underwent surgery and relapsed after 5 months and 9 years, respectively. Immunohistochemical staining was positive for human melanoma black-45 in the present 3 cases. The aim of the present study was to focus the attention of clinicians on this type of hepatic tumor in order to improve its diagnosis and treatment.

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“…Hepatic hemorrhage as a complication of ruptured HAML is very rare and has only been described in a few case reports to date. [13][14][15] The current study had several limitations. First, selection bias was likely given the retrospective design.…”

Section: Discussionmentioning

confidence: 92%

Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome

Klompenhouwer

Dwarkasing

Doukas

et al. 2020

HPB

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Background: Hepatic angiomyolipoma (HAML) may easily be misdiagnosed as a malignancy. The study aim was to assess diagnostic dilemmas, clinical management and outcome of this rare tumor.Methods: This retrospective international multicenter study included all patients with pathologically proven HAML diagnosed between 1997 and 2017. Data on patient characteristics, diagnostic work-up, management and follow-up were analyzed.Results: Thirty-eight patients were included, 32 female. Median age was 56yrs (i.q.r. 43-64) and median HAML-diameter was 57.5 mm (i.q.r. 38.5-95.3). Thirty patients had undergone CT and 27/38 MRI of the liver, diagnostic biopsy was performed in 19/38. Initial diagnosis was incorrect in 15/38 patients, of which 13 were thought to have malignancy. In 84% biopsy resulted in a correct preoperative diagnosis. Twenty-nine patients were managed with surgical resection, 4/38 with surveillance and 3/38 with liver transplantation. Recurrence after resection occurred in two cases. No HAML related deaths or progression to malignancy were documented. Conclusion:HAML diagnosis proved problematic even in hepatobiliary expertise centers. Biopsy is indicated and may provide valuable additional information when HAML diagnosis is considered on cross-sectional imaging, especially when surgical resection imposes a risk of complications. Conservative management with regular imaging follow-up might be justified when biopsy confirms (classic type) HAML.

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Ruptured Hepatic Epithelioid Angiomyolipoma: A Case Report and Literature Review

Cited by 17 publications

References 16 publications

Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis

Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis

Hepatic epithelioid angiomyolipoma is a rare and potentially severe but treatable tumor: A report of three cases and review of the literature

Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome

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