Russell body gastritis

Habib, Claudine; Gang, David L.; Ghaoui, Rony; Pantanowitz, Liron

doi:10.1002/ajh.21702

Cited by 17 publications

(9 citation statements)

References 10 publications

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“…There are insufficient data about the etiology and progression of this entity. A possible relationship between H. pylori -negative RBG and the immune status has been proposed, with a number of cases reported in patients with HIV[ 10 - 12 ], alcohol[ 10 , 16 , 22 ] and drug abuse[ 10 , 13 , 16 ] and post-transplant patients[ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature

Peruhova

Peshevska-Sekulovska

Georgieva

et al. 2020

WJG

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BACKGROUND Russell body gastritis (RBG) is very rare type of chronic inflammation of gastric mucosa. The pathologic hallmark of the disease is Russell bodies (RB) which represent accumulation of eosinophilic cytoplasmic inclusions in endoplasmic reticulum of mature plasma cells (Mott cells). Most published cases are associated with Helicobacter pylori ( H. pylori ) infection because of correlation between plasma cell activation and antigenic stimulation. There are insufficient data about H. pylori -negative RBG and very little is known about the natural course of the disease. CASE SUMMARY A 51-year-old male patient underwent endoscopic screening for mild iron deficiency anemia. Gastroscopy revealed diffuse hyperemia, edema and nodularity of the fundic and corpus mucosa. Due to non-specific endoscopic findings and iron-deficiency anemia our preliminary diagnosis was diffuse type of gastric carcinoma or gastric lymphoma. Biopsy specimens of gastric mucosa showed inflammatory infiltrate rich in Mott cells, consisting entirely of cytoplasmic RB. Absence of nuclear atypia and mitosis of the plasma cells, polyclonal pattern of the Mott cells and negative staining for cytokeratins favored diagnosis of RBG. The patient was treated with proton-pump inhibitor for 8 wk. Long-term clinical and endoscopic surveillance was scheduled. Albeit, there was no improvement in endoscopic features of the gastric mucosa in three consecutive gastroscopies, histopathological findings demonstrated that the chronic inflammatory infiltrate in the fundic mucosa is less pronounced, rich in plasma cells, with almost absent RB and Mott cells. CONCLUSION The prognosis of this entity is uncertain, that is why these patients are subjects of continuous follow up.

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Section: Discussionmentioning

confidence: 99%

Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature

Peruhova

Peshevska-Sekulovska

Georgieva

et al. 2020

WJG

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“…The Russell bodies are accumulations of immunoglobulins, particularly immunoglobulin G (IgG), in the endoplasmic reticulum of plasma cells, with a globular or morular appearance. However, currently it is known that plasma cells are present in chronic inflammatory reactions caused by prolonged antigenic stimulation, as in HIV infection [25][26][27][28]. The reason why these immunoglobulins crystallize in the cytoplasm remains unclear [29,30].…”

Section: Discussionmentioning

confidence: 99%

Reduction of immunity in HIV-infected individuals: Can fibrosis induce hypoplasia in palatine and lingual tonsils of individuals with HIV infection?

Beghini

Montes

Rodrigues

et al. 2015

Pathology - Research and Practice

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“…The presence of diffuse plasma cell infiltration with Russell body formation is suggestive of an interaction between HP infection and gastric immune system, since this agent determines a chronic inflammatory process in the gastric mucosa. The over-stimulation of plasma cells by mucosal pathogens could lead to the accumulation of excess amounts of IgG in the cytoplasm (3,4,8,12,14,18) .…”

Section: Discussionmentioning

confidence: 99%

“…Signet-ring cell carcinoma show an infiltrative growth pattern, nuclear atypia, cells with clear and vacuolated cytoplasma, mitotic activity, and a positive immunoexpression for cytokeratins. Plasma cells associated with Russell body demonstrate homogeneous eosinophilic round inclusions that stain intensely in the PAS method, and are immunopositive for the antibodies CD79a, CD138, and kappa and lambda imunoglobulin light chain (1,2,4,5,8,9,14,16) . The authors suggest the use of the term gastritis with Russell bodies, since the presence of these corpuscles represents a cell alteration and not a cause of the disease.…”

Section: Discussionmentioning

confidence: 99%

Russell body gastritis: case report

Cambruzzi¹,

Pêgas²,

Laus

2012

J. Bras. Patol. Med. Lab.

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Primeira submissão em 16/04/11 Última submissão em 29/10/11 Aceito para publicação em 05/12/11 Publicado em 20/02/12 Russell body gastritis (RBG), which can be associated with Helicobacter pylori (HP) infection, is a recently acknowledged lesion characterized by the presence of eosinophilic intracytoplasmic inclusions in plasmacytes. Herein the authors discuss the morphological aspects of a case of RBG in a male patient with clinical complaint of epigastric pain. Upper endoscopy revealed areas of erythema/edema in the antrum. As far as microscopy is concerned, a mononuclear inflammatory infiltrate was identified on the lamina propria, with plasma cells containing Schiff acid periodic (PAS) positive eosinophilic intracytoplasmic globules, which showed positive immunostaining for CD79a, CD138, and kappa/lambda light chains. HP was identified by Giemsa stains.

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Russell body gastritis

Cited by 17 publications

References 10 publications

Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature

Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature

Reduction of immunity in HIV-infected individuals: Can fibrosis induce hypoplasia in palatine and lingual tonsils of individuals with HIV infection?

Russell body gastritis: case report

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