Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity

Solution equilibrium studies of anticancer ruthenium(II)-η6-p-cymene complexes of pyridinecarboxylic acids

“…7). The pyridine-N is able to coordinate monodentately to the Ru center in absence of a second donor atom to act as a chelating ligand [36]. In order to exclude the possibility of the formation of bis-ligand Ru(II)(η 6 -p-cymene) complexes of the pyridinecarboxylates in which one of the ligands binds via the (N,O) donor set and the other monodentately, pH-dependent 1 H NMR spectra were recorded at 1:2 metal-to-ligand ratio (not shown).…”

“…Furthermore, the ligand can also modify the interaction with different biomolecules such as albumin, transferrin or various cellular proteins. Grgurić-Šipka, Gligorijević and co-workers studied the biological activity of Ru(II)( 6 -p-cymene) complexes of various pyridine derivatives and moderate-tolow cytotoxicity was found in six tumour cell lines; although the complex of picolinic acid (pic) represents an enhanced antiproliferative activity [26,36]. As these complexes are considered as prodrugs, the knowledge of their speciation and the most plausible chemical forms in aqueous solution in the biologically relevant pH range is a mandatory prerequisite for understanding the alterations in their biological activity.…”

“…In order to compare the differences in speciation and thus in the stability of the complexes order of biological activity [28,30,36,[47][48][49]. …”

Half-sandwich ruthenium(II) complexes with N- and N,(N,O)-donor ligands: molecular, electronic structures, and computational study

“…In addition, the arene ligands stabilize the ruthenium ?2 oxidation state, which makes the corresponding complexes kinetically more labile when compared to those of ruthenium(III). Furthermore, the hydrogen bonding and p-stacking are important in mechanisms of biological activity and the complexes are able to present these interactions [15][16][17]. The benzimidazole and benzoxazole ligands are interesting due to their biological activity and the derivatives used as ligands in this work are a good representative of these derivatives.…”

Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η6-toluene) complexes of picolinate derivatives

“…The Ru(II) precursor [Ru(η 6 -toluene)Cl(μ-Cl)] 2 and the complexes of picH, 3-Me-picH, 5-BrpicH, 2,4-dipicH 2 and 2,5-dipicH 2 (Chart 1) were obtained according to the literature procedure used for the analogous Ru(η 6 -p-cymene) complexes [25][26][27][28]. Pure compounds (1)(2)(3)(4)(5) were isolated from methanol or 2-propanol with moderate yields 50-58%.…”