Ruthenium(II) complexes containing 2,9-dimethyl-1,10-phenanthroline and 4,4′-dimethyl-2,2′-bipyridine as ancillary ligands: synthesis, characterization and DNA-binding

Abstract

Two new Ruthenium (II) polypyridyl complexes [Ru(dmp) 2 (ipbp)](ClO 4 ) 2 (1) (dmp = 2,9-dimethyl-1,10-phenanthroline, ipbp = 3-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-4H-1-banzopyran-2-one) and [Ru(dmb) 2 (ipbp)](ClO 4 ) 2 (2) (dmb = 4,4 0 -dimethyl-2,2 0 -bipyridine) have been synthesized and characterized by elemental analysis, FAB-MS, ES-MS and 1 H NMR and cyclic voltammetric methods. The DNA-binding behaviors of these complexes were investigated by spectroscopic titration, viscosity measurements, and thermal denaturation. Absorption titration and thermal denaturation studies reveal that these complexes are moderately strong binders of calf thymus DNA (CT-DNA). Viscosity measurements show that the complexes 1 and 2 interact with CT-DNA by intercalative mode. The DNA-binding affinity of the complex 2 is larger than that of complex 1.

DNA binding and photocleavage properties of two mixed-ligand oxovanadium complexes

“…DNA-binding metal complexes, especially those with small molecular weight, have been extensively studied as DNA structural and conformational probes, DNA-dependent electron transfer and sequence-specific cleaving agents, and potential anticancer drugs [4][5][6]. As a trace bioelement existing in the human body, vanadium has been found to present a variety of biological activities such as antitumor, antimicrobial and insulin-enhancing effects, and its complexes have therefore been widely studied in order to promote these pharmacological effects and concomitantly reduce toxicity [7][8][9][10].…”

Synthesis of heterocyclic compounds and its applications

“…The K b values for the complexes are found in the order of 10 4 -10 5 and change in hypochromism of the complexes is found in the range of 16-27%. The values of observed hypochromism and redshift of around 3-4 nm suggests the intercalative mode of binding of complexes (Liu et al, 2008). Obtained K b value is found higher than [Ru(dmp) 2 (ipbp)] +2 (dmp = 2,9-dimethyl-1,10-phenanthroline, ipbp = 3-(1H-imidazo[4,5-f][1,10]phe nanthrolin-2-yl)-4H-1-banzopyran-2-one) (7.58 · 10 3 M À1 ) Liu et al, 1999, but …”

Antimicrobial and Spectral Studies of Zinc Metal Complexes Derived From Imidazo [4, 5-F] [1, 10] – Phenanthroline Derivative

“…[9] The imidazole ring in organic molecules has been The primary interest has been the search for discovery of DNA probe materials that possess site/pH-specific interactions with certain base residues of known DNA macromolecules. [14][15][16] With respect to these facts it is quite surprising that literature did not reveal synthesis, characterization and antimicrobial activity to explore the coordination chemistry of transition metal complexes with ligands of heterocyclic substituted 1H-imidazo [4, 5-f] [1,10] phenanthroline derivatives. This has prompted us to synthesize and antimicrobial studies of metal complexes involving this ligand.…”